Relationship of urinary myelin basic protein-like material with cranial magnetic resonance imaging in advanced multiple sclerosis

John N WHITAKER; Jerry S WOLINSKY; Ponnada A NARAYANA; Alfred A BARTOLUCCI; John H NOSEWORTHY; Fred D LUBLIN; Anders LINDE; Per GJÖRSTRUP; Herman C SULLIVAN; North American Linomide Investigators

doi:10.1001/archneur.58.1.49

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Relationship of urinary myelin basic protein-like material with cranial magnetic resonance imaging in advanced multiple sclerosis

Journal article

Open access

Peer reviewed

Relationship of urinary myelin basic protein-like material with cranial magnetic resonance imaging in advanced multiple sclerosis

John N WHITAKER, Jerry S WOLINSKY, Ponnada A NARAYANA, Alfred A BARTOLUCCI, John H NOSEWORTHY, Fred D LUBLIN, Anders LINDE, Per GJÖRSTRUP, Herman C SULLIVAN and North American Linomide Investigators

Archives of neurology (Chicago), Vol.58(1), pp.49-54

2001

DOI: 10.1001/archneur.58.1.49

PMID: 11176936

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Abstract

Background: A significant correlation exists between disability and the volume of black holes (BHL VOL), defined as hypointense lesions on T1-weighted cranial magnetic resonance imaging. A consistent correlation has also been reported between urinary myelin basic protein-like material (MBPLM) and the transition toward secondary progression (SP) from relapsing-remitting (RR) multiple sclerosis (MS). Objective: To improve the management of MS through a noninvasive and cost-effective test for monitoring disease activity or disease status. Design and methods: From 662 patients with MS (86 with RR MS, 259 with SP MS without continued attacks, and 317 with SP MS with continued attacks), 24-hour urine samples were obtained at enrollment in the phase 3 Linomide (roquinimex) drug study. The urine specimens were analyzed for MBPLM and correlated with clinical features and findings on cranial magnetic resonance imaging. Results: Significant but weak correlations existed between urinary MBPLM and BHL VOL in all patients with MS (r = 0.114, P =.003; n = 662), patients with SP MS without attacks (r = 0.185, P =.003; n = 259), and all patients with SP MS (r = 0.122, P =.003; n = 576). No significant correlations were detected in the RR MS group or any of the disease groups or subgroups whose Expanded Disability Status Scale score was 5.0 or lower. In subgroup analysis, the most significant correlation was detected between urinary MBPLM after adjustment for creatinine and BHL VOL in patients with SP MS with an Expanded Disability Status Scale score of 5.5 or higher but without continued relapses (r = 0.417, P<.001; n = 138). Conclusions: In patients with advanced SP MS, urinary MBPLM may possibly serve as an indicator of failed remission and axonal damage. Urinary MBPLM correlates with disease status in MS, especially the transition of RR MS to SP MS with advancing disability.

Neurology

Biological and medical sciences

Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis

Medical sciences

Details

Title: Subtitle: Relationship of urinary myelin basic protein-like material with cranial magnetic resonance imaging in advanced multiple sclerosis
Creators: John N WHITAKER - Department of Neurology, University of Alabama at Birmingham, United States
Jerry S WOLINSKY - Department of Neurology, University of Texas at Houston Health Science Center, Rochester, United States
Ponnada A NARAYANA - Department of Radiology, University of Texas at Houston Health Science Center, United States
Alfred A BARTOLUCCI - Department of Biostatistics, University of Alabama at Birmingham, United States
John H NOSEWORTHY - Department of Neurology, Mayo Clinic, Rochester, Minn, United States
Fred D LUBLIN - Department of Neurology, Allegheny University of the Health Sciences, Philadelphia, Pa, United States
Anders LINDE - Pharmacia and Upjohn, Kalamazoo, Mich, United States
Per GJÖRSTRUP - Pharmacia and Upjohn, Kalamazoo, Mich, United States
Herman C SULLIVAN - Pharmacia and Upjohn, Kalamazoo, Mich, United States
North American Linomide Investigators
Contributors: John Kamholz (Contributor) - University of Iowa, Neurology
Resource Type: Journal article
Publication Details: Archives of neurology (Chicago), Vol.58(1), pp.49-54
DOI: 10.1001/archneur.58.1.49
PMID: 11176936
NLM abbreviation: Arch Neurol
ISSN: 0003-9942
eISSN: 1538-3687
Publisher: American Medical Association; Chicago, IL
Language: English
Date published: 2001
Academic Unit: Neurology; Psychiatry
Record Identifier: 9984020782802771

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