Relationships between myocardial perfusion, myocardial necrosis, and technetium--99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion

M L Marcus; R J Tomanek; J C Ehrhardt; R E Kerber; D D Brown; F M Abboud

doi:10.1161/01.cir.54.4.647

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Relationships between myocardial perfusion, myocardial necrosis, and technetium--99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion

Journal article

Open access

Peer reviewed

Relationships between myocardial perfusion, myocardial necrosis, and technetium--99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion

M L Marcus, R J Tomanek, J C Ehrhardt, R E Kerber, D D Brown and F M Abboud

Circulation (New York, N.Y.), Vol.54(4), p.647

10/1976

DOI: 10.1161/01.cir.54.4.647

PMID: 183915

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Abstract

The quantitative relationship between abnormalities seen on technetium-99m pyrophosphate (99mTc-PYP) infarct scintigrams and the size of the myocardial infarction is unclear. We evaluated two possible determinants of 99mTc-PYP accumulation: myocardial perfusion measured with 7-10 mu microspheres and the extent of necrosis determined histologically. Hemodynamics and myocardial perfusion to small segments of the left ventricle were measured prior to, 5-10 min, and 44-48 hours following sudden occlusion of the left anterior descending coronary artery in ten awake dogs. 99mTc-PYP was injected i.v. following the third injection of microspheres and the animals were killed 2 hours later. The important findings were as follows: 1) there is a close relationship between the extent of myocardial necrosis observed and the perfusion of segments 5-10 min following coronary occlusion; and 2) that segmental myocardial perfusion is an important determinant of 99mTc-PYP accumulation by myocardial segments which contain areas of necrosis. Although the present data preclude statistical analysis of the relationship between the level of necrosis in a segment and the accumulation of 99mTc-PYP by that segment, the two do not appear to be related, a finding which would discourage use of intensity of 99mTc-PYP images for infarct size. The distribution of an abnormality on the scintigram may provide an estimate of infarct size. However, the geometry of the infarct and the resolving power of the scanning equipment will significantly limit this in many clinical situations.

Coronary Circulation

Myocardial Infarction - diagnosis

Diphosphates - metabolism

Male

Myocardium - pathology

Technetium

Necrosis

Animals

Perfusion

Myocardial Infarction - pathology

Myocardium - metabolism

Dogs

Female

Disease Models, Animal

Details

Title: Subtitle: Relationships between myocardial perfusion, myocardial necrosis, and technetium--99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion
Creators: M L Marcus
R J Tomanek
J C Ehrhardt
R E Kerber
D D Brown
F M Abboud
Resource Type: Journal article
Publication Details: Circulation (New York, N.Y.), Vol.54(4), p.647
DOI: 10.1161/01.cir.54.4.647
PMID: 183915
NLM abbreviation: Circulation
ISSN: 0009-7322
eISSN: 1524-4539
Publisher: Lippincott Williams & Wilkins; United States
Language: English
Date published: 10/1976
Academic Unit: Radiology; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984025330002771

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