Journal article
Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years
Pediatric research, Vol.94(5), pp.1720-1730
11/2023
DOI: 10.1038/s41390-021-01778-y
PMCID: PMC9023615
PMID: 34686832
Abstract
Background Severe retinopathy of prematurity (ROP) is associated with adverse outcomes. Relationships between milder ROP and outcomes have not been defined. We hypothesized that children with ROP stage <= 3 who did not receive ophthalmologic intervention would have worse motor, cognitive, and language skills and more vision abnormalities than children without ROP. Methods This was a secondary analysis of a randomized trial evaluating the effects of myo-inositol on ROP in the NICHD Neonatal Research Network. Primary outcomes were Bayley Scales of Infant Development composite scores; secondary outcomes included behavioral difficulties and ophthalmologic measures. Outcomes were compared using adjusted linear or modified Poisson models. Results Of 506 children, 173 (34%) had no ROP, 262 (52%) had ROP stage <= 3 without intervention, and 71 (14%) had ROP with intervention. There was no difference in motor, cognitive, or language scores between children with ROP stage <= 3 without intervention and children without ROP. Children with ROP stage <= 3 without intervention had a higher rate of strabismus compared to children without ROP (p = 0.040). Conclusion Children with ROP stage <= 3 without intervention did not have adverse neurodevelopmental outcomes at 2 years' corrected age compared to children without ROP but did have an increased incidence of strabismus. Impact This study addresses a gap in the literature regarding the relationship between milder forms of retinopathy of prematurity (ROP) that regress without intervention and neurodevelopment and vision outcomes. Children with a history of ROP stage <= 3 without intervention have similar neurodevelopmental outcomes at 2 years' corrected age as children born extremely preterm without a history of ROP and better outcomes than children with a history of ROP with ophthalmologic intervention. Counseling about likely neurodevelopment and vision outcomes for children born extremely preterm with a history of ROP may be tailored based on the severity of ROP.
Details
- Title: Subtitle
- Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years
- Creators
- Jane E. Brumbaugh - Mayo Clinic in FloridaEdward F. Bell - University of IowaShawn C. Hirsch - RTI InternationalEmma G. Crenshaw - RTI InternationalSara B. DeMauro - University of PennsylvaniaIra S. Adams-Chapman - Emory UniversityJean R. Lowe - University of New MexicoGirija Natarajan - Wayne State UniversityMyra H. Wyckoff - The University of Texas Southwestern Medical CenterBetty R. Vohr - Brown UniversityTarah T. Colaizy - University of IowaHeidi M. Harmon - University of IowaKristi L. Watterberg - University of New MexicoSusan R. Hintz - Stanford UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.94(5), pp.1720-1730
- Publisher
- Springer Nature
- DOI
- 10.1038/s41390-021-01778-y
- PMID
- 34686832
- PMCID
- PMC9023615
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Number of pages
- 11
- Grant note
- NICHD; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) UL1 TR41; UL1 TR42; UL1 TR77; UL1 TR93; UL1 TR442; UL1 TR454; UL1 TR1117 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Eye Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) U10 HD36790; UG1 HD27904; UG1 HD21364; UG1 HD68284; UG1 HD27853; UG1 HD40492; UG1 HD27851; UG1 HD27856; UG1 HD87229; UG1 HD68278; UG1 HD27880; UG1 HD34216; UG1 HD68270; UG1 HD53109; UG1 HD53089; UG1 HD68244; UG1 HD68263; UG1 HD40689; UG1 HD21385 / Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
- Language
- English
- Electronic publication date
- 10/22/2021
- Date published
- 11/2023
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354158702771
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