Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma

Hrvoje Bogunović; Young H Kwon; Adnan Rashid; Kyungmoo Lee; Douglas B Critser; Mona K Garvin; Milan Sonka; Michael D Abràmoff

doi:10.1167/iovs.14-15885

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Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma

Journal article

Open access

Peer reviewed

Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma

Hrvoje Bogunović, Young H Kwon, Adnan Rashid, Kyungmoo Lee, Douglas B Critser, Mona K Garvin, Milan Sonka and Michael D Abràmoff

Investigative ophthalmology & visual science, Vol.56(1), pp.259-271

12/09/2014

DOI: 10.1167/iovs.14-15885

PMCID: PMC4294288

PMID: 25491294

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Abstract

To determine relationships between spectral-domain optical coherence tomography (SD-OCT) derived regional damage to the retinal ganglion cell-axonal complex (RGC-AC) and visual thresholds for each location of the Humphrey 24-2 visual field, in all stages of open-angle glaucoma. Patients with early, moderate, and advanced glaucoma were recruited from a tertiary glaucoma clinic. Humphrey 24-2 and 9-field Spectralis SD-OCT were acquired for each subject. Individual OCT volumes were aligned, nerve fiber layer (NFL), ganglion cell and inner plexiform layers (GCL+IPL) cosegmented. These layers were then partitioned into 54 sectors corresponding to the 24-2 grid. A Support Vector Machine was trained independently for each sector to predict the sector threshold, using these structural properties. One hundred twenty-two consecutive subjects, 43 early, 39 moderate, and 40 advanced, glaucoma were included (122 eyes). Average correlation coefficient (R) was 0.68 (0.47-0.82), and average root mean square error (RMSE) was 6.92 dB (3.93-8.68 dB). Prediction performance averaged over the entire field, superior hemifield, and inferior hemifield had R (RMSE) values of 0.77 (3.76), 0.80 (5.05), and 0.84 (3.80) dB, respectively. Predicting individual 24-2 visual field thresholds from structural information derived from nine-field SD-OCT local NFL and GCL+IPL thicknesses using the RGC-AC concept is feasible, showing the potential for the predictive ability of SD-OCT structural information for visual function. Ultimately, it may be feasible to complement and reduce the burden of subjective visual field testing in glaucoma patients with predicted function derived objectively from OCT.

Visual Field Tests - methods

Visual Fields - physiology

Prospective Studies

Tomography, Optical Coherence

Humans

Middle Aged

Glaucoma, Open-Angle - diagnosis

Glaucoma, Open-Angle - physiopathology

Male

Retinal Ganglion Cells - pathology

Young Adult

Adolescent

Aged, 80 and over

Adult

Female

Aged

Details

Title: Subtitle: Relationships of retinal structure and humphrey 24-2 visual field thresholds in patients with glaucoma
Creators: Hrvoje Bogunović - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
Young H Kwon - Stephen A. Wynn Institute for Vision Research, University of Iowa, Iowa City, Iowa, United States Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
Adnan Rashid - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
Kyungmoo Lee - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
Douglas B Critser - Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
Mona K Garvin - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States
Milan Sonka - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States
Michael D Abràmoff - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States
Resource Type: Journal article
Publication Details: Investigative ophthalmology & visual science, Vol.56(1), pp.259-271
DOI: 10.1167/iovs.14-15885
PMID: 25491294
PMCID: PMC4294288
NLM abbreviation: Invest Ophthalmol Vis Sci
ISSN: 0146-0404
eISSN: 1552-5783
Publisher: United States
Grant note: R01 EY019112 / NEI NIH HHS R01 EB004640 / NIBIB NIH HHS R01 EY018853 / NEI NIH HHS
Language: English
Date published: 12/09/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; The University of Iowa Institute for Vision Research; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
Record Identifier: 9983806391402771

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