Journal article
Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
Genes, Vol.11(6), pp.645-9
06/11/2020
DOI: 10.3390/genes11060645
PMID: 32545271
Abstract
There is increasing evidence of gastrointestinal (GI) infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We surveyed the co-expression of SARS-CoV-2 entry genes ACE2 and TMPRSS2 throughout the GI tract to assess potential sites of infection. Publicly available and in-house single-cell RNA-sequencing datasets from the GI tract were queried. Enterocytes from the small intestine and colonocytes showed the highest proportions of cells co-expressing ACE2 and TMPRSS2. Therefore, the lower GI tract represents the most likely site of SARS-CoV-2 entry leading to GI infection.
Details
- Title: Subtitle
- Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract
- Creators
- Jaewon J. Lee - The University of Texas MD Anderson Cancer CenterScott Kopetz - The University of Texas MD Anderson Cancer CenterEduardo Vilar - The University of Texas MD Anderson Cancer CenterJohn Paul Shen - The University of Texas MD Anderson Cancer CenterKen Chen - The University of Texas MD Anderson Cancer CenterAnirban Maitra - The University of Texas MD Anderson Cancer Center
- Resource Type
- Journal article
- Publication Details
- Genes, Vol.11(6), pp.645-9
- DOI
- 10.3390/genes11060645
- PMID
- 32545271
- NLM abbreviation
- Genes (Basel)
- ISSN
- 2073-4425
- eISSN
- 2073-4425
- Publisher
- MDPI
- Language
- English
- Date published
- 06/11/2020
- Academic Unit
- Surgery
- Record Identifier
- 9985240896002771
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