Journal article
Relative Regional Air Volume Change Maps at the Acinar Scale Reflect Variable Ventilation in Low Lung Attenuation of COPD patients
Academic radiology, Vol.27(11), pp.1540-1548
11/01/2020
DOI: 10.1016/j.acra.2019.12.004
PMID: 32024604
Abstract
Objectives: The purpose of this study was to investigate regional air volume changes at the acinar scale of the lung in chronic obstructive pulmonary disease (COPD) patients using an image registration technique.
Materials and Methods: Thirty-four emphysema patients and 24 subjects with normal chest CT and pulmonary function test (PFT) results were included in this retrospective study for which informed consent was waived by the institutional review board. After lung segmentation, a mass-preserving image registration technique was used to compute relative regional air volume changes (RRAVCs) between inspiration and expiration CT scans. After determining the appropriate thresholds of RRAVCs for low ventilation areas (LVAs), they were displayed and analyzed using color maps on the background inspiration CT image, and compared with the low attenuation area (LAA) map. Correlations between quantitative CT parameters and PFTs were assessed using Pearson's correlation test, and parameters were compared between emphysema and normal-CT patients using the Student's t-test.
Results: LVA percentage with an RRAVC threshold of 0.5 (%LVA(0.5)) showed the strongest correlations with FEV1/FVC (r = -0.566), FEV1 (r = 0.534), %LAA_(950insp) (r = 0.712), and %LAA_(856exp) (r = 0.775). %LVA(0.5) was significantly higher (P < 0.001) in COPD patients than normal subjects. Despite the identical appearance of emphysematous lesions on the LAA_(950insp) map, the RRAVC map depicted a wide range of ventilation differences between these LM clusters.
Conclusion: RRAVC-based %LVA(0.5) correlated well with FEV1/FVC, FEV1, %LAA_(950insp) and %LAA_(856exp). RRAVC holds the potential for providing additional acinar scale functional information for emphysematous LAAs in inspiratory CT images, providing the basis for a novel set for emphysematous phenotypes.
Details
- Title: Subtitle
- Relative Regional Air Volume Change Maps at the Acinar Scale Reflect Variable Ventilation in Low Lung Attenuation of COPD patients
- Creators
- Kum Ju Chae - Jeonbuk National UniversityJiwoong Choi - University of IowaGong Yong Jin - Jeonbuk National UniversityEric A. Hoffman - University of IowaArchana T. Laroia - University of IowaMargaret Park - Seoul National University HospitalChang Hyun Lee - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Academic radiology, Vol.27(11), pp.1540-1548
- DOI
- 10.1016/j.acra.2019.12.004
- PMID
- 32024604
- NLM abbreviation
- Acad Radiol
- ISSN
- 1076-6332
- eISSN
- 1878-4046
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- 2017R1D1A1A09082160 / Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education 2018001360001 / Korea Environment Industry & Technology Institute (KEITI) through Environmental Health Action Program - Korea Ministry of Environment (MOE)
- Language
- English
- Date published
- 11/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Mechanical Engineering; Internal Medicine
- Record Identifier
- 9984318815502771
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