Relative afferent pupillary defects in patients with Leber hereditary optic neuropathy and unilateral visual loss

D M Jacobson; E M Stone; N R Miller; S C Pollock; W A Fletcher; P J McNussen; T J Martin

doi:10.1016/S0002-9394(98)00152-4

Back

Relative afferent pupillary defects in patients with Leber hereditary optic neuropathy and unilateral visual loss

Journal article

Open access

Peer reviewed

Relative afferent pupillary defects in patients with Leber hereditary optic neuropathy and unilateral visual loss

D M Jacobson, E M Stone, N R Miller, S C Pollock, W A Fletcher, P J McNussen and T J Martin

American journal of ophthalmology, Vol.126(2), pp.291-295

08/1998

DOI: 10.1016/S0002-9394(98)00152-4

PMID: 9727524

Files and links (1)

url

https://doi.org/10.1016/S0002-9394(98)00152-4View

Published (Version of record) Open Access

Abstract

It has been suggested that the pupillary light reaction is relatively preserved in the affected eyes of patients with Leber hereditary optic neuropathy (LHON). To test the hypothesis that visual-pupillomotor dissociation exists in LHON, we performed a retrospective study to evaluate the magnitude of the relative afferent pupillary defect (RAPD) in patients who had experienced monocular visual loss. We also compared the size of the measured RAPD with the size of the RAPD that would be expected on the basis of documented visual field loss. We identified a cohort of patients with LHON and monocular visual loss, whose pupillary reactions had been quantified using neutral density filters. From a review of the case records, we determined whether an RAPD was present, as well as the magnitude of the documented RAPDs. We also calculated the expected size of the RAPD for each patient, using previously established templates that correlated the size of the RAPD with the degree of visual field loss. An RAPD was identified in all 10 patients in this study. There was no significant difference between the size of the measured and predicted RAPD, nor did the size of the RAPD correlate with visual acuity or the time interval between the onset of visual loss and evaluation. The results of this study do not support the hypothesis that visual-pupillomotor dissociation is a common feature of LHON.

Humans

Middle Aged

Pupil Disorders - physiopathology

Afferent Pathways - physiopathology

Male

Vision, Monocular

Reflex, Pupillary

Visual Fields

Light

Adolescent

Blindness

Iris - innervation

Adult

Female

Retrospective Studies

Optic Atrophies, Hereditary - physiopathology

Child

Pupil Disorders - complications

Cohort Studies

Diagnostic Techniques, Ophthalmological

Optic Atrophies, Hereditary - complications

Details

Title: Subtitle: Relative afferent pupillary defects in patients with Leber hereditary optic neuropathy and unilateral visual loss
Creators: D M Jacobson - Department of Neurology, Marshfield Clinic, Wisconsin 54449, USA. jacobsod@mfldclin.edu
E M Stone
N R Miller
S C Pollock
W A Fletcher
P J McNussen
T J Martin
Resource Type: Journal article
Publication Details: American journal of ophthalmology, Vol.126(2), pp.291-295
DOI: 10.1016/S0002-9394(98)00152-4
PMID: 9727524
NLM abbreviation: Am J Ophthalmol
ISSN: 0002-9394
eISSN: 1879-1891
Publisher: United States
Language: English
Date published: 08/1998
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979911502771

Metrics

11 Record Views

18 Times Cited - Web of Science