Journal article
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
QJM : monthly journal of the Association of Physicians, Vol.106(8), pp.721-729
08/2013
DOI: 10.1093/qjmed/hct093
PMCID: PMC3713590
PMID: 23620537
Abstract
Background:
Hyperuricemia is known to be a risk factor for incident type 2 diabetes mellitus, but the absolute magnitude of the association is not known. We aimed to evaluate the strength of association between hyperuricemia and the risk of developing diabetes among the US veterans with gout.
Methods
: Patients (age ≥ 18 years) with ≥2 clinical encounters with gout diagnoses, no history of inflammatory diseases or diabetes and two serum urate (sUA) measurements between 1 January 2002 and 1 January 2011 were selected. Diabetes was identified using International Classification of Disease-9-Clinical Modification codes, use of anti-diabetic medications or HbA1c ≥6.5%. sUA levels were assessed at 6-month cycles (hyperuricemia: sUA >7 mg/dl). Accumulated hazard curves for time to first diabetes diagnosis were derived from Kaplan–Meier (KM) analysis. Risk of diabetes associated with hyperuricemia was estimated using a Cox proportional hazards model. Population attributable fraction (AF) of new-onset diabetes within 1 year was estimated using logistic regression.
Results
: Among 1923 patients, average age was 62.9 years, body mass index was 30.6 kg/m
2
, and follow-up time was 80 months. Diabetes rates from KM were 19% for sUA ≤ 7 mg/dl, 23% for 7 mg/dl < sUA ≤ 9 mg/dl and 27% for sUA > 9 mg/dl at the end of follow-up period (
P
< 0.001). Hyperuricemia was associated with a significantly higher risk of developing diabetes, after adjusting for confounding factors (hazard ratio: 1.19, 95% confidence interval: [1.01–1.41]). Approximately, 8.7% of all new cases of diabetes were statistically attributed to hyperuricemia.
Conclusions
: Among veterans, hyperuricemia was associated with excess risk for developing diabetes. Approximately, 1 in 11 new cases of diabetes were statistically attributed to hyperuricemia.
Details
- Title: Subtitle
- Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout
- Creators
- E Krishnan - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAK.S Akhras - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAH Sharma - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAM Marynchenko - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAE.Q Wu - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAR Tawk - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAJ Liu - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USAL Shi - From the Department of Medicine, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA, Takeda Pharmaceuticals International Inc. One Takeda Parkway, Deerfield, IL 60015, USA, Analysis Group, Inc. 111 Huntington Ave., Boston, MA 02199, USA and Tulane University, 1440 Canal Street, New Orleans, LA 70112, USA
- Resource Type
- Journal article
- Publication Details
- QJM : monthly journal of the Association of Physicians, Vol.106(8), pp.721-729
- Publisher
- Oxford University Press
- DOI
- 10.1093/qjmed/hct093
- PMID
- 23620537
- PMCID
- PMC3713590
- ISSN
- 1460-2725
- eISSN
- 1460-2393
- Language
- English
- Date published
- 08/2013
- Academic Unit
- Health Management and Policy
- Record Identifier
- 9984214956302771
Metrics
8 Record Views