Release of a humoral vasodilator substance during neurogenic vasodilatation

Dennis R Ballard; Francois M Abboud; Howard E Mayer

doi:10.1152/ajplegacy.1970.219.5.1451

Back

Release of a humoral vasodilator substance during neurogenic vasodilatation

Journal article

Peer reviewed

Release of a humoral vasodilator substance during neurogenic vasodilatation

Dennis R Ballard, Francois M Abboud and Howard E Mayer

The American journal of physiology, Vol.219(5), pp.1451-1457

11/1970

DOI: 10.1152/ajplegacy.1970.219.5.1451

PMID: 5473134

View Online

Abstract

Vascular responses to direct nerve stimulation were studied in anesthetized dogs. After pretreatment with reserpine or the administration of guanethidine, nerve stimulation caused vasodilatationin the isolated perfused gracilis and paw. These dilator responses were observed in prevenous resistance vessels and not in venous segments. The dilatation in the muscle was transient and was blocked by atropine. The dilatation in the paw was sustained for several minutes after the end of stimulation and was not altered by atropine plus tripelennamine. This dilator response in the paw was associated with the release of a vasodilator substance in the venous effluent which could be assayed by perfusing the venous effluent into the contralateral paw at constant rate and measuring pressor responses. The effect of the vasodilator substance on the assay paw was not blocked by atropine, tripelennamine, propranolol, or carboxypeptidase injected in doses sufficient to antagonize corresponding agonists. The results indicate that a noncholinergic dilator system supplies prevenous resistance vessels of the paw and causes the release of a vasodilator substance when it is activated.

Blood Pressure

Blood Vessels - innervation

Vascular Resistance

Carboxypeptidases - pharmacology

Vasodilator Agents - antagonists & inhibitors

Atropine - pharmacology

Male

Vasodilator Agents - secretion

Arteries

Propranolol - pharmacology

Animals

Sympathetic Nervous System - physiology

Time Factors

Venous Pressure

Dilatation

Hindlimb - blood supply

Perfusion

Blood Flow Velocity

Dogs

Reserpine - pharmacology

Biological Assay

Muscles - blood supply

Guanethidine - pharmacology

Tripelennamine - pharmacology

Details

Title: Subtitle: Release of a humoral vasodilator substance during neurogenic vasodilatation
Creators: Dennis R Ballard
Francois M Abboud
Howard E Mayer
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.219(5), pp.1451-1457
DOI: 10.1152/ajplegacy.1970.219.5.1451
PMID: 5473134
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: American Physiological Society; United States
Language: English
Date published: 11/1970
Academic Unit: Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984025423002771

Metrics

9 Record Views

35 Times Cited - Web of Science