Reliability, Asymmetry, and Age Influence on Dynamic Cerebral Autoregulation Measured by Spontaneous Fluctuations of Blood Pressure and Cerebral Blood Flow Velocities in Healthy Individuals

Santiago Ortega‐Gutierrez; Nils Petersen; Arjun Masurkar; Andres Reccius; Amy Huang; Min Li; Jae H Choi; Randolph S Marshall

doi:10.1111/jon.12019

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Reliability, Asymmetry, and Age Influence on Dynamic Cerebral Autoregulation Measured by Spontaneous Fluctuations of Blood Pressure and Cerebral Blood Flow Velocities in Healthy Individuals

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Reliability, Asymmetry, and Age Influence on Dynamic Cerebral Autoregulation Measured by Spontaneous Fluctuations of Blood Pressure and Cerebral Blood Flow Velocities in Healthy Individuals

Santiago Ortega‐Gutierrez, Nils Petersen, Arjun Masurkar, Andres Reccius, Amy Huang, Min Li, Jae H Choi and Randolph S Marshall

Journal of neuroimaging, Vol.24(4), pp.379-386

07/2014

DOI: 10.1111/jon.12019

PMCID: PMC4812577

PMID: 23607680

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Abstract

BACKGROUND Cerebral autoregulation (CA) enables the brain to maintain stable cerebral blood flow (CBF). CA can be assessed noninvasively by determining correlations between CBF velocity (CBFV) and spontaneous changes in blood pressure. Postrecording signal analysis methods have included both frequency‐ and time‐domain methods. However, the test‐retest reliability, cross‐validation, and determination of normal values have not been adequately established. METHODS In 53 healthy volunteers, a transfer function analysis was applied to calculate phase shift (PS) and gain in the low frequency range (.06‐.12 Hz) where CA is most apparent. Correlation analysis was used to derive mean velocity index (Mx). Intraclass correlation and bivariate correlation coefficients were applied to assess asymmetry, cross‐validity, and test‐retest results: The bihemispheric average PS, gain, and Mx means were 45.99+/−14.24°, .62+/−.38 cm/second/mmHg, and .41+/−.13, respectively. Gain exhibited a difference by age (P = .03). PS, gain, and Mx values showed excellent interhemispheric correlation (r > .8; P < .001). PS and gain showed good reliability (R ICC = .632, L ICC = .576; P < .001). PS and Mx showed fair correlation (r = −.37; P < .001). CONCLUSIONS CA parameters obtained by time‐ and frequency‐domain methods correlate well, and show good interhemispheric and test‐retest reliability. Group means from healthy controls may provide adequate norms for determining abnormal CA in cerebrovascular patients.

autoregulatory index

Cerebral autoregulation

transcranial Doppler phase shift

gain

Details

Title: Subtitle: Reliability, Asymmetry, and Age Influence on Dynamic Cerebral Autoregulation Measured by Spontaneous Fluctuations of Blood Pressure and Cerebral Blood Flow Velocities in Healthy Individuals
Creators: Santiago Ortega‐Gutierrez - Columbia University
Nils Petersen - Columbia University
Arjun Masurkar - Columbia University
Andres Reccius - Universidad del Desarrollo
Amy Huang - Columbia University
Min Li - The Fourth Military Medical University
Jae H Choi - Columbia University
Randolph S Marshall - Columbia University
Resource Type: Journal article
Publication Details: Journal of neuroimaging, Vol.24(4), pp.379-386
DOI: 10.1111/jon.12019
PMID: 23607680
PMCID: PMC4812577
NLM abbreviation: J Neuroimaging
ISSN: 1051-2284
eISSN: 1552-6569
Number of pages: 8
Language: English
Date published: 07/2014
Academic Unit: Neurology; Radiology; Iowa Neuroscience Institute; Neurosurgery
Record Identifier: 9984020748302771

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