Journal article
Reliability of heart rate variability during stable and disrupted polysomnographic sleep
American journal of physiology. Heart and circulatory physiology, Vol.323(1), pp.H16-H23
07/01/2022
DOI: 10.1152/ajpheart.00143.2022
PMID: 35559723
Abstract
Heart rate variability (HRV) is commonly used within sleep and cardiovascular research, yet HRV reliability across various sleep stages remains equivocal. The present study examined the reliability of frequency- and time-domain HRV within stage-2 (N2), slow-wave (SWS), and rapid-eye-movement (REM) sleep during both stable and disrupted sleep. We hypothesized that high-frequency (HF) HRV would be reliable in all three sleep stages, low-frequency (LF) HRV would be reliable during N2 and SWS, and that disrupted sleep via spontaneous cortical arousals would decrease HRV reliability. Twenty-seven participants (11 men, 16 women, 26 ± 1 yr) were equipped with laboratory polysomnography for 1 night. Both frequency- and time-domain HRV were analyzed in two 5- to 10-min blocks during multiple stable and disrupted sleep cycles across N2, SWS, and REM sleep. HF HRV was highly correlated across stable N2 (
= 0.839,
< 0.001), SWS (
= 0.765,
< 0.001), and REM (
= 0.881,
< 0.001). LF HRV was moderate-to-highly correlated during stable cycles of N2 sleep (
= 0.694,
< 0.001), SWS, (
= 0.765,
< 0.001), and REM (
= 0.699,
< 0.001) sleep. When stable sleep was compared with disrupted sleep, both time- and frequency-domain HRV were reliable (α > 0.90,
< 0.05) in N2, SWS, and REM, except for LF HRV during SWS (α = 0.62,
= 0.089). In conclusion, time- and frequency-domain HRV demonstrated reliability across stable N2, SWS, and REM sleep, and remained reliable during disrupted sleep. These findings support the use of HRV during sleep as a tool for assessing cardiovascular health and risk stratification.
Heart rate variability (HRV) is a commonly employed indirect estimate of cardiac autonomic activity during sleep with limited reliability studies. Nocturnal frequency-domain HRV was reliable across differing stable sleep cycles of stage-2 (N2), slow-wave (SWS), and rapid-eye-movement (REM) sleep. Moreover, frequency- and time-domain HRV were reliable during stable and disturbed sleep, except SWS low-frequency HRV. Our finding supports nocturnal HRV as a potential tool for cardiovascular risk stratification.
Details
- Title: Subtitle
- Reliability of heart rate variability during stable and disrupted polysomnographic sleep
- Creators
- Emma M Kerkering - Montana State UniversityIan M Greenlund - Montana State UniversityJeremy A Bigalke - Montana State UniversityGianna C L Migliaccio - Montana State UniversityCarl A Smoot - Montana State UniversityJason R Carter - Montana State University
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.323(1), pp.H16-H23
- DOI
- 10.1152/ajpheart.00143.2022
- PMID
- 35559723
- NLM abbreviation
- Am J Physiol Heart Circ Physiol
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Grant note
- U54GM115371 / HHS | National Institutes of Health (NIH) R01AA024892 / HHS | National Institutes of Health (NIH) P20GM103474 / HHS | National Institutes of Health (NIH) R01 AA024892 / NIAAA NIH HHS U54 GM115371 / NIGMS NIH HHS P20 GM103474 / NIGMS NIH HHS
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9985219855002771
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