Reliability of targeting methods in TMS for depression: Beam F3 vs. 5.5 cm

Nicholas T Trapp; Joel Bruss; Marcie King Johnson; Brandt D Uitermarkt; Laren Garrett; Amanda Heinzerling; Chaorong Wu; Timothy R Koscik; Patrick Ten Eyck; Aaron D Boes

doi:10.1016/j.brs.2020.01.010

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Reliability of targeting methods in TMS for depression: Beam F3 vs. 5.5 cm

Journal article

Open access

Reliability of targeting methods in TMS for depression: Beam F3 vs. 5.5 cm

Nicholas T Trapp, Joel Bruss, Marcie King Johnson, Brandt D Uitermarkt, Laren Garrett, Amanda Heinzerling, Chaorong Wu, Timothy R Koscik, Patrick Ten Eyck and Aaron D Boes

Brain stimulation, Vol.13(3), pp.578-581

05/2020

DOI: 10.1016/j.brs.2020.01.010

PMCID: PMC7507589

PMID: 32289680

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Abstract

No consensus exists in the clinical transcranial magnetic stimulation (TMS) field as to the best method for targeting the left dorsolateral prefrontal cortex (DLPFC) for depression treatment. Two common targeting methods are the Beam F3 method and the 5.5 cm rule. Evaluate the anatomical reliability of technician-identified DLPFC targets and obtain consensus average brain and scalp MNI152 coordinates. Three trained TMS technicians performed repeated targeting using both the Beam F3 method and 5.5 cm rule in ten healthy subjects (n = 162). Average target locations were plotted on 7T structural MRIs to compare inter- and intra-rater reliability, respectively. (1) Beam F3 inter- and intra-rater reliability was superior to 5.5 cm targeting (p = 0.0005 and 0.0035). (2) The average Beam F3 location was 2.6±1.0 cm anterolateral to the 5.5 cm method. Beam F3 targeting demonstrates greater precision and reliability than the 5.5 cm method and identifies a different anatomical target.

Reproducibility of Results

Humans

Prefrontal Cortex - physiopathology

Magnetic Resonance Imaging - methods

Adult

Female

Male

Transcranial Magnetic Stimulation - methods

Depression - therapy

Prefrontal Cortex - diagnostic imaging

Details

Title: Subtitle: Reliability of targeting methods in TMS for depression: Beam F3 vs. 5.5 cm
Creators: Nicholas T Trapp - Department of Psychiatry, University of Iowa, Iowa City, IA, United States. Electronic address: nicholas-trapp@uiowa.edu
Joel Bruss - Department of Neurology, University of Iowa, Iowa City, IA, United States
Marcie King Johnson - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, United States
Brandt D Uitermarkt - Department of Pediatrics, University of Iowa, Iowa City, IA, United States
Laren Garrett - Department of Psychiatry, University of Iowa, Iowa City, IA, United States
Amanda Heinzerling - Department of Psychiatry, University of Iowa, Iowa City, IA, United States
Chaorong Wu - Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, United States
Timothy R Koscik - Department of Psychiatry, University of Iowa, Iowa City, IA, United States
Patrick Ten Eyck - Institute for Clinical and Translational Science, University of Iowa, Iowa City, IA, United States
Aaron D Boes - Department of Psychiatry, University of Iowa, Iowa City, IA, United States; Department of Neurology, University of Iowa, Iowa City, IA, United States; Department of Pediatrics, University of Iowa, Iowa City, IA, United States
Resource Type: Journal article
Publication Details: Brain stimulation, Vol.13(3), pp.578-581
DOI: 10.1016/j.brs.2020.01.010
PMID: 32289680
PMCID: PMC7507589
NLM abbreviation: Brain Stimul
ISSN: 1935-861X
eISSN: 1876-4754
Publisher: United States
Grant note: T32 MH019113 / NIMH NIH HHS S10 RR028821 / NCRR NIH HHS T32 GM108540 / NIGMS NIH HHS UL1 TR002537 / NCATS NIH HHS K12 NS098482 / NINDS NIH HHS
Language: English
Date published: 05/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Psychiatry; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Biostatistics; Neurology (Pediatrics); Design Biostat and Ethics
Record Identifier: 9984070414802771

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