Journal article
Reliability of the Charcot‐Marie‐Tooth functional outcome measure
Journal of the peripheral nervous system, Vol.25(3), pp.288-291
09/2020
DOI: 10.1111/jns.12406
PMCID: PMC7520097
PMID: 32844461
Abstract
The CMT‐FOM is a 13‐item clinical outcome assessment (COA) that measures physical ability in adults with Charcot‐Marie‐Tooth disease (CMT). Test‐retest reliability, internal consistency and convergent validity have been established for the CMT‐FOM. This current study sought to establish inter‐rater reliability. Following an in‐person training of six international clinical evaluators we recruited 10 participants with genetically diagnosed CMT1A, (aged 18‐74 years, 6 female). Participants were evaluated using the CMT‐FOM over 2 days. Participants were given at least a 3 hour rest between evaluations, and were assessed twice each day. Following the provision of training by master trainers, all 13 items of the CMT‐FOM exhibited excellent inter‐rater reliability for raw scores (ICC1,1 0.825‐0.989) and z‐scores (ICC1,1 0.762‐0.969). Reliability of the CMT‐FOM total score was excellent (ICC1,1 0.983, 95% CI 0.958‐0.995). The CMT‐FOM is a reliable COA used by clinical evaluators internationally. The next steps are to establish further validation through psychometric evaluation of the CMT‐FOM in the Accelerate Clinical Trials in CMT (ACT‐CMT) study.
Details
- Title: Subtitle
- Reliability of the Charcot‐Marie‐Tooth functional outcome measure
- Creators
- Paula Bray - University of Sydney, School of Health Sciences & The Children's Hospital at WestmeadKayla M. D Cornett - University of Sydney, School of Health Sciences & The Children's Hospital at WestmeadTimothy Estilow - Hospital of the University of PennsylvaniaDavide Pareyson - Istituto Neurologico Carlo BestaRiccardo Zuccarino - Neuromuscular Omnicentre (NEMO)‐Fondazione Serena OnlusMariola Skorupinska - UCL Queen Square Institute of NeurologyMenelaos Pipis - UCL Queen Square Institute of NeurologyJanet E Sowden - University of RochesterSteven Scherer - Hospital of the University of PennsylvaniaMary M Reilly - UCL Queen Square Institute of NeurologyMichael E Shy - Carver College of MedicineDavid N Herrmann - University of RochesterJoshua Burns - University of Sydney, School of Health Sciences & The Children's Hospital at WestmeadKaty J Eichinger - University of Rochester
- Resource Type
- Journal article
- Publication Details
- Journal of the peripheral nervous system, Vol.25(3), pp.288-291
- Publisher
- Wiley Periodicals, Inc; Malden, USA
- DOI
- 10.1111/jns.12406
- PMID
- 32844461
- PMCID
- PMC7520097
- ISSN
- 1085-9489
- eISSN
- 1529-8027
- Number of pages
- 4
- Grant note
- National Institutes of Health (NIH 1 U01 NS109403‐02)
- Language
- English
- Date published
- 09/2020
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984070152402771
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