Journal article
Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry
CrystEngComm, Vol.21(13), pp.2049-2052
03/25/2019
DOI: 10.1039/C8CE00764K
Abstract
Nano-dimensional single crystals of acetylsalicylic acid (aspirin) Form I are generated through sonocrystallization and are shown to exhibit Young's modulus values in the MPa range, which is significantly softer (5-fold reduction) than macro-dimensional single crystals. The change is attributed to structural consequences of the size-dependent surface-to-volume ratio effect, particularly as related to intermolecular forces.
Details
- Title: Subtitle
- Remarkable decrease in stiffness of aspirin crystals upon reducing crystal size to nanoscale dimensions via sonochemistry
- Creators
- Kristin M Hutchins - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USAThilini P Rupasinghe - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USAShalisa M Oburn - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USAKamal K Ray - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USAAlexei V Tivanski - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USALeonard R MacGillivray - Department of Chemistry, University of Iowa, Iowa City, 52242-1294 USA
- Resource Type
- Journal article
- Publication Details
- CrystEngComm, Vol.21(13), pp.2049-2052
- DOI
- 10.1039/C8CE00764K
- ISSN
- 1466-8033
- eISSN
- 1466-8033
- Grant note
- DOI: 10.13039/100000192, name: National Oceanic and Atmospheric Administration, award: NA11OAR4310187; DOI: 10.13039/100000078, name: Division of Materials Research, award: DMR-1708673
- Language
- English
- Date published
- 03/25/2019
- Academic Unit
- Chemistry; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9983985804102771
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