Journal article
Remodeling of Cerebral Arterioles in Chronic Hypertension
Hypertension (Dallas, Tex. 1979), Vol.13(6, Part 2), pp.968-972
06/1989
DOI: 10.1161/01.HYP.13.6.968
PMID: 2737731
Abstract
Chronic hypertension impairs dilatation of cerebral arterioles. Impairment of dilatation generally has been attributed to hypertrophy of the vessel wall with encroachment on the vascular lumen. In this study, we tested the hypothesis that a reduction in external diameter may contribute to encroachment on the vascular lumen during chronic hypertension. We examined 10–12-month-old, anesthetized Wistar-Kyoto (WKY) rats and stroke-prone spontaneously hypertensive rats (SHRSP). External diameter, stress, and strain of pial arterioles were calculated from measurements of pial arteriolar pressure (servo null), diameter, and crosssectional area of the arteriolar wall. During maximal dilatation produced with ethylenediaminetetraacetic acid, cross-sectional area of the arteriolar wall was greater in SHRSP than in WKY rats (2,038±57 vs. 1,456±61 μm2, p < 0.05). External, as well as internal, diameter was less in SHRSP than in WKY rats (101+3 and 88±3 /tm in SHRSP vs. 111±3 and 102±3 fim in WKY rats for external and internal diameter, respectively, p < 0.05). Reduction in external diameter accounted for 76% of encroachment on the lumen in SHRSP, and hypertrophy per se accounted for only 24%. Distensibility of deactivated pial arterioles was increased in SHRSP. These findings suggest that reduction in external diameter plays an important role in impairment of maximal dilatation of cerebral arterioles in SHRSP, and reduction in vascular diameter in SHRSP cannot be accounted for by altered distensibility. We propose that, during chronic hypertension, cerebral arterioles undergo structural remodeling that results in a smaller external diameter and encroachment on the vascular lumen. Reduction in external diameter appears to account for most of the impairment of cerebral vasodilatation that occurs in chronic hypertension.
Details
- Title: Subtitle
- Remodeling of Cerebral Arterioles in Chronic Hypertension
- Creators
- Gary Baumbach - University of Iowa College of Medicine, Departments of Pathology, Internal Medicine, and Pharmacology, Cardiovascular Center, and the VA Medical Center, Iowa City, IowaDonald Heistad
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.13(6, Part 2), pp.968-972
- DOI
- 10.1161/01.HYP.13.6.968
- PMID
- 2737731
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- American Heart Association, Inc
- Language
- English
- Date published
- 06/1989
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040551802771
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