Journal article
Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium
Biological psychiatry. Cognitive neuroscience and neuroimaging, Vol.7(9), pp.935-948
09/2022
DOI: 10.1016/j.bpsc.2022.02.008
PMCID: PMC9835553
PMID: 35307575
Abstract
Background
Posttraumatic stress disorder (PTSD) is accompanied by disrupted cortical neuroanatomy. We investigated alteration in covariance of structural networks associated with PTSD in regions that demonstrate the case-control differences in cortical thickness (CT) and surface area (SA).
Methods
Neuroimaging and clinical data were aggregated from 29 research sites in >1300 PTSD cases and >2000 trauma-exposed control subjects (ages 6.2–85.2 years) by the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta Analysis–Psychiatric Genomics Consortium) PTSD working group. Cortical regions in the network were rank ordered by the effect size of PTSD-related cortical differences in CT and SA. The top-n (n = 2–148) regions with the largest effect size for PTSD > non-PTSD formed hypertrophic networks, the largest effect size for PTSD < non-PTSD formed atrophic networks, and the smallest effect size of between-group differences formed stable networks. The mean structural covariance (SC) of a given n-region network was the average of all positive pairwise correlations and was compared with the mean SC of 5000 randomly generated n-region networks.
Results
Patients with PTSD, relative to non-PTSD control subjects, exhibited lower mean SC in CT-based and SA-based atrophic networks. Comorbid depression, sex, and age modulated covariance differences of PTSD-related structural networks.
Conclusions
Covariance of structural networks based on CT and cortical SA are affected by PTSD and further modulated by comorbid depression, sex, and age. The SC networks that are perturbed in PTSD comport with converging evidence from resting-state functional connectivity networks and networks affected by inflammatory processes and stress hormones in PTSD.
Details
- Title: Subtitle
- Remodeling of the Cortical Structural Connectome in Posttraumatic Stress Disorder: Results From the ENIGMA-PGC Posttraumatic Stress Disorder Consortium
- Creators
- Delin Sun - Duke UniversityGopalkumar Rakesh - Duke UniversityEmily K Clarke-RubrightCourtney C Haswell - Duke UniversityMark W Logue - Boston University School of MedicineErin N O’LearyAndrew S Cotton - University of ToledoHong Xie - University of ToledoEmily L Dennis - University of UtahNeda Jahanshad - Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.Lauren E Salminen - Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.Sophia I Thomopoulos - Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.Faisal M Rashid - Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.Christopher R.K Ching - Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.Saskia B.J Koch - Radboud University NijmegenJessie L Frijling - Amsterdam University Medical CentersLaura Nawijn - Amsterdam UMC Location Vrije Universiteit AmsterdamMirjam van Zuiden - Amsterdam University Medical CentersXi Zhu - Columbia University Irving Medical CenterBenjamin Suarez-Jimenez - Columbia University Irving Medical CenterAnika Sierk - Charité - Universitätsmedizin BerlinHenrik Walter - Charité - Universitätsmedizin BerlinAntje Manthey - Charité - Universitätsmedizin BerlinJennifer S Stevens - Emory UniversityNegar Fani - Emory UniversitySanne J.H van Rooij - Emory UniversityMurray B Stein - University of California San DiegoJessica Bomyea - University of California San DiegoInga Koerte - Brigham and Women's HospitalKyle Choi - University of California San DiegoSteven J.A van der WerffRobert R.J.M VermeirenJulia I Herzog - Central Institute of Mental HealthLauren A.M Lebois - McLean HospitalJustin T BakerKerry J Ressler - McLean HospitalElizabeth A OlsonThomas Straube - University of MünsterMayuresh S Korgaonkar - Westmead InstituteElpiniki Andrew - The University of SydneyYe Zhu - Chinese Academy of Social SciencesGen Li - Chinese Academy of Social SciencesJonathan Ipser - University of Cape TownAnna R HudsonMatthew Peverill - University of WashingtonKelly Sambrook - University of WashingtonEvan Gordon - Baylor UniversityLee A Baugh - University of South DakotaGina Forster - University of South DakotaRaluca M Simons - University of South DakotaJeffrey S Simons - University of South DakotaVincent A Magnotta - University of IowaAdi Maron-Katz - Stanford UniversityStefan du Plessis - Stellenbosch UniversitySeth G Disner - Minneapolis VA Health Care SystemNicholas D Davenport - Minneapolis VA Health Care SystemDan GrupeJack B Nitschke - University of Wisconsin–MadisonTerri A deRoon-Cassini - Medical College of WisconsinJacklynn Fitzgerald - Marquette UniversityJohn H Krystal - National Center for PTSDIfat Levy - National Center for PTSDMiranda Olff - Amsterdam University Medical CentersDick J Veltman - Amsterdam University Medical CentersLi Wang - Chinese Academy of Social SciencesYuval Neria - Columbia University Irving Medical CenterMichael D De Bellis - Duke UniversityTanja Jovanovic - Wayne State UniversityJudith K Daniels - University of GroningenMartha E Shenton - VA Boston Healthcare SystemNic J.A van de Wee - Leiden University Medical CenterChristian Schmahl - Central Institute of Mental HealthMilissa L Kaufman - McLean HospitalIsabelle M Rosso - McLean HospitalScott R Sponheim - Minneapolis VA Health Care SystemDavid Bernd HofmannRichard A Bryant - UNSW SydneyKelene A Fercho - University of South DakotaDan J Stein - University of Cape TownSven MüllerK. Luan PhanKatie A McLaughlin - Harvard UniversityRichard J Davidson - University of Wisconsin–MadisonChristine Larson - University of Wisconsin–MilwaukeeGeoffrey May - The University of Texas at DallasSteven M Nelson - The University of Texas at DallasChadi G Abdallah - Yale UniversityHassaan Gomaa - Pennsylvania State UniversityAmit Etkin - VA Palo Alto Health Care SystemSoraya Seedat - Stellenbosch UniversityIlan Harpaz-Rotem - National Center for PTSDIsrael Liberzon - University of MichiganXin Wang - University of ToledoPaul M Thompson - Imaging Genetics Center, Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of USC, Marina del Rey, CA, USA.Rajendra A Morey - Duke University
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry. Cognitive neuroscience and neuroimaging, Vol.7(9), pp.935-948
- DOI
- 10.1016/j.bpsc.2022.02.008
- PMID
- 35307575
- PMCID
- PMC9835553
- NLM abbreviation
- Biol Psychiatry Cogn Neurosci Neuroimaging
- ISSN
- 2451-9022
- eISSN
- 2451-9030
- Publisher
- Elsevier BV
- Grant note
- DOI: 10.13039/100005902, name: UW Institute for Clinical and Translational Research; DOI: 10.13039/100000025, name: National Institute of Mental Health; DOI: 10.13039/100006108, name: NCATS; DOI: 10.13039/100000874, name: NARSAD; DOI: 10.13039/100000738, name: US Department of Veterans Affairs; DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism; DOI: 10.13039/501100001659, name: German Research Foundation; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences; DOI: 10.13039/100000097, name: National Center for Research Resources; DOI: 10.13039/100009633, name: National Institute of Child Health and Human Development; DOI: 10.13039/100000864, name: Michael J Fox Foundation for Parkinson's Research; DOI: 10.13039/501100000925, name: NHMRC; DOI: 10.13039/501100001322, name: South African Medical Research Council; DOI: 10.13039/100000049, name: National Institute on Aging; DOI: 10.13039/100000065, name: National Institute of Neurological Disorders and Stroke; DOI: 10.13039/100000070, name: National Institute of Biomedical Imaging and Bioengineering; DOI: 10.13039/100000026, name: National Institute on Drug Abuse; DOI: 10.13039/501100003180, name: Academic Medical Center; DOI: 10.13039/100006380, name: VA RR&D; DOI: 10.13039/100001068, name: Dana Foundation; DOI: 10.13039/100000005, name: US Department of Defense; DOI: 10.13039/501100001826, name: Netherlands Organisation for Health Research and Development
- Language
- English
- Date published
- 09/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984378113702771
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