Journal article
Removal of hyperpolarized Xe-129 gas-phase contamination in spectroscopic imaging of the lungs
Magnetic resonance in medicine, Vol.80(6), pp.2586-2597
12/01/2018
DOI: 10.1002/mrm.27349
PMCID: PMC6291357
PMID: 29893992
Abstract
Purpose: A novel technique is presented for retrospective estimation and removal of gas-phase hyperpolarized Xenon-129 (HP Xe-129) from images of HP Xe-129 dissolved in the barrier (comprised of parenchymal lung tissue and blood plasma) and red blood cell (RBC) phases. The primary aim is mitigating RF pulse performance limitations on measures of gas exchange (e.g., barrier-gas and RBC-gas ratios). Correction for gas contamination would simplify technical dissemination of HP Xe-129 applications across sites with varying hardware performance, scanner vendors, and models.
Methods: Digital lung phantom and human subject experiments (N = 8 healthy; N = 1 with idiopathic pulmonary fibrosis) were acquired with 3D radial trajectory and 1-point Dixon spectroscopic imaging to assess the correction method for mitigating barrier and RBC imaging artifacts. Dependence of performance on TE, image SNR, and gas contamination level were characterized. Inter-and intra-subject variation in the dissolved-phase ratios were quantified and compared to human subject experiments before and after correction.
Results: Gas contamination resulted in image artifacts similar to those in disease that were mitigated after correction in both simulated and human subject data; for simulation experiments performance varied with TE, but was independent of image SNR and the amount of gas contamination. Artifacts and variation of barrier and RBC components were reduced after correction in both simulation and healthy human lungs (barrier, P = 0.01; RBC, P = 0.045).
Conclusion: The proposed technique significantly reduced regional variations in barrier and RBC ratios, separated using a 1-point Dixon approach, with improved accuracy of dissolved-phase HP Xe-129 images confirmed in simulation experiments.
Details
- Title: Subtitle
- Removal of hyperpolarized Xe-129 gas-phase contamination in spectroscopic imaging of the lungs
- Creators
- Andrew D. Hahn - University of Wisconsin–MadisonJeff Kammerman - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.80(6), pp.2586-2597
- DOI
- 10.1002/mrm.27349
- PMID
- 29893992
- PMCID
- PMC6291357
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- NIH/NHLBI R01 HL126771; NIH/NCRR 1 S10 OD016394; NIH/NCATS UL1 TR000427 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA S10OD016394 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA UL1TR002373 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) R01HL126771 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 12/01/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275058802771
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