Journal article
Renal Artery Stenosis Modifies Glomerular Injury in Antineutrophil Cytoplasmic Antibody-Associated Disease
American journal of kidney diseases, Vol.20(5), pp.509-512
11/1992
DOI: 10.1016/S0272-6386(12)70266-4
PMID: 1359784
Abstract
A 68-year-old man presented with renal failure, heart failure, gastrointestinal bleeding, and a pulmonary infiltrate. Serologic evaluation revealed a perinuclear antineutrophil cytoplasmic antibody (ANCA) at a titer of 1:1280, which on immunoblot and enzyme immunoassay showed antimyeloperoxidase specificity. Autopsy showed microscopic polyarteritis based on the presence of necrotizing alveolitis and crescentic glomerulonephritis. The extent and activity of the glomerular disease was modified by a right renal artery stenosis (RAS). Twenty percent of glomeruli on the right and 82% glomeruli on the left contained crescentic lesions. Furthermore, predominantly active lesions were associated with renal artery stenosis, while the contralateral kidney contained mostly organized crescents. This observation suggests that hemodynamic factors or its sequelae can influence the onset and severity of ANCA-associated disease.
Details
- Title: Subtitle
- Renal Artery Stenosis Modifies Glomerular Injury in Antineutrophil Cytoplasmic Antibody-Associated Disease
- Creators
- Stephen M BonsibJames A Goeken
- Resource Type
- Journal article
- Publication Details
- American journal of kidney diseases, Vol.20(5), pp.509-512
- DOI
- 10.1016/S0272-6386(12)70266-4
- PMID
- 1359784
- ISSN
- 0272-6386
- eISSN
- 1523-6838
- Language
- English
- Date published
- 11/1992
- Academic Unit
- Pathology
- Record Identifier
- 9984203946202771
Metrics
6 Record Views