Journal article
Renal Changes in Cocaine Abuse and Addiction
Acta medica Bulgarica, Vol.46(2), pp.57-61
05/01/2019
DOI: 10.2478/amb-2019-0020
Abstract
Cocaine is a natural alkaloid extracted from the leaves of the South American plant Erythroxylum coca or synthesized chemically. After cannabis, it is the second most frequently abused recreational substance worldwide. Cocaine can affect every tissue and organ within the human body, including the kidneys, causing tissue ischemia due to vasoconstriction, endothelial dysfunction and damage, procoagulant activity and oxidative stress with subsequent ischemic infarctions and fibrosis. The renal changes in cocaine abuse and addiction are due to rhabdomyolysis, ischemic, hypertensive, and inflammatory changes with the development of cell proliferation and fibrosis. The authors present three patients with cocaine-associated renal damage and discuss the underlying mechanisms of cocaine-induces tissue changes.
Details
- Title: Subtitle
- Renal Changes in Cocaine Abuse and Addiction
- Creators
- M. Nikolova - Medical University of SofiaVl Milenova - Medical University of SofiaD. Yosifov - Medical University of SofiaY. Vlahov - Sofia University "St. Kliment Ohridski"V. Tenev - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Acta medica Bulgarica, Vol.46(2), pp.57-61
- DOI
- 10.2478/amb-2019-0020
- ISSN
- 0324-1750
- eISSN
- 0324-1750
- Publisher
- Sciendo
- Number of pages
- 5
- Language
- English
- Date published
- 05/01/2019
- Academic Unit
- Psychiatry
- Record Identifier
- 9984296357902771
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