Journal article
Renal Hemodynamics and Natriuresis Induced by the Dopamine-1 Agonist, SKF 82526
The American journal of the medical sciences, Vol.294(3), pp.181-186
09/1987
DOI: 10.1097/00000441-198709000-00009
PMID: 2889360
Abstract
The intrarenal infusion of dopamine (DA) during alpha- and beta-adrenergic blockade has been reported to increase renal blood flow (RBF) and sodium excretion by occupation of DA-1 receptors. In addition, DA may potentially influence renal function by occupation of DA-2 receptor subtypes. This study was designed to examine the hemodynamic and/or tubular mechanisms of the natriuretic effect of DA-1 in dogs anesthetized with pentobarbital. The intrarenal infusion of the DA-1 agonist, SKF 82526 (10−9, 10−8, 10−7M), resulted in dose related increases in RBF and absolute and fractional sodium excretion. These changes were not associated with alterations in urinary prostaglandin E2, F2 alpha, or kallikrein excretion. To determine the role of RBF in the natriuresis due to SKF 82526 infusion (10−7M), the renal artery was constricted to return RBF to control levels during continued SKF 82526 infusion. Although absolute and fractional sodium excretion decreased during this maneuver, they remained higher than control. These studies support both a hemodynamic and a tubular mechanism for the natriuretic effect of the DA-1 agonist, SKF 82526. These effects do not appear to be mediated by the renal prostaglandin or kallikrein systems.
Details
- Title: Subtitle
- Renal Hemodynamics and Natriuresis Induced by the Dopamine-1 Agonist, SKF 82526
- Creators
- Pedro A Jose - Georgetown University Medical Center, Washington, DCGilbert M Eisner - Georgetown University Medical Center, Washington, DCJean E Robillard - Iowa University Medical Center, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.294(3), pp.181-186
- Publisher
- Elsevier Inc
- DOI
- 10.1097/00000441-198709000-00009
- PMID
- 2889360
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 09/1987
- Academic Unit
- Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
- Record Identifier
- 9984025696702771
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