Journal article
Renal Iron Accumulation and Oxidative Injury With Aging: Effects of Treatment With an Iron Chelator
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.75(4), pp.680-684
03/09/2020
DOI: 10.1093/gerona/glz055
PMID: 30794723
Abstract
Abstract
Dysregulation of iron metabolism in the kidney may contribute to age-related increases in renal oxidative stress and dysfunction. This study assessed the effects of short-term iron chelation on markers of iron status, oxidative stress, inflammation, and autophagy in the kidneys of old rats. Old Fischer 344 rats (24 months) were treated with deferoxamine (DFO; 200 mg/kg, twice daily for 4.5 days); saline-treated young (6 months) and old rats served as controls. Renal nonheme iron was significantly higher in the old rats, with iron localized in the renal cortex. Ferritin levels were elevated in the kidneys of old rats, while expression of several antioxidant enzymes and mitochondrial proteins were reduced and protein carbonyls increased compared to young rats. DFO treatment significantly reduced ferritin levels, and increased transferrin receptor-1 protein, but did not affect nonheme iron content or protein carbonyls, nor did it reverse age-related changes in antioxidant enzymes and mitochondrial proteins. Although short-term DFO treatment did not mitigate the age-related increase in iron content and oxidative damage, this work demonstrates that old rats respond appropriately to DFO, suggesting that optimization of iron chelation regimens could be useful in improving renal homeostasis with aging.
Details
- Title: Subtitle
- Renal Iron Accumulation and Oxidative Injury With Aging: Effects of Treatment With an Iron Chelator
- Creators
- Steven A Bloomer - Division of Science and Engineering, Penn State University, Abington College, PennsylvaniaKyle E Brown - Iowa City Veterans Administration Medical Center, IowaKevin C Kregel - Department of Health and Human Physiology, The University of Iowa, Iowa City
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.75(4), pp.680-684
- Publisher
- Oxford University Press
- DOI
- 10.1093/gerona/glz055
- PMID
- 30794723
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Grant note
- name: Penn State University, Abington College; DOI: 10.13039/100000002, name: National Institutes of Health, award: AG-12350
- Language
- English
- Date published
- 03/09/2020
- Academic Unit
- Gastroenterology and Hepatology; Radiation Oncology; Provost Office Administration; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984213451902771
Metrics
6 Record Views