Logo image
Back
Renal and Adrenal Responses to Hypoxemia during Angiotensin-Converting Enzyme Inhibition in Lambs
Journal article   Open access   Peer reviewed

Renal and Adrenal Responses to Hypoxemia during Angiotensin-Converting Enzyme Inhibition in Lambs

Douglas Weismann, James Herrig, Oliva McWeeny, Nancy Ayres and Jean Robillard
Circulation research, Vol.52(2), pp.179-187
02/1983
DOI: 10.1161/01.RES.52.2.179
PMID: 6297830
url
https://doi.org/10.1161/01.RES.52.2.179View
Published (Version of record) Open Access

Abstract

Chronically catheterized lambs (4–37 days postnatal age) (n =35) were studied to test the hypothesis that the products of angiotensin-converting enzyme activity are involved in renal and adrenal responses to normocapnic hypoxemia in immature lambs.HYPOXEMIA as a perinatal complication may pro-foundly affect renal function and result in renal in-sufficiency (Cort, 1962; Torrado et al., 1974; Guignard et al., 1976; Dauber et al., 1976; Broberger and Aperia, 1978). The renin-angiotensin-aldosterone (RAA) sys-tem has been suggested as a possible regulator of hemodynamic responses to pathophysiological con-ditions such as hypoxemia (Mattioli et al., 1975; Al-ward et al., 1978; Robillard et al., 1981). Furthermore, activity of the RAA system varies with postnatal age, including postnatal age-related differences in produc-tion of, and response to, angiotensin II, the vasocon-strictor product of angiotensin-converting enzyme ac-tivity (Skeggs et al., 1976; Pipkin et al., 1974; Mott, 1975; Siegel and Fisher, 1977; Siegel and Fisher, 1980; Wallace et al., 1980a, 1980b; Siegel, 1981).

Details

Metrics

2 Record Views
19 Times Cited - Web of Science
Logo image