Journal article
Renal clearances of oxypurinol and inulin on an isocaloric, low‐protein diet
Clinical pharmacology and therapeutics, Vol.43(6), pp.681-687
06/1988
DOI: 10.1038/clpt.1988.95
PMID: 3378389
Abstract
In previous studies a low‐calorie, low‐protein diet caused a sustained reduction in both oxypurinol and uric acid renal clearances (CLR). With the hypothesis that the decrease in CLR was due to the low‐protein and not the low‐caloric content of the diet, we studied the CLR of oxypurinol, uric acid, creatinine, and inulin in normal subjects during isocaloric (2600 calories per 70 kg per day), normal‐protein (150 gm per day), and low‐protein (19 gm per day) diets. There were three major findings: (1) the CLR of oxypurinol declined from 26.6 ± 1.8 ml/min on the normal‐protein diet to 13.5 ± 1.4 ml/min on the isocaloric low‐protein diet (p < 0.05); (2) the CLR of inulin and creatinine fell 14% and 20%, respectively, on the low‐protein diet compared with the normal‐protein diet (both p < 0.05); and (3) there was a diurnal variation in the CLR of oxypurinol. We conclude that the decreased CLR of oxypurinol was the result of the reduced protein content of the diet and the CLR of both inulin and creatinine were decreased on the low‐protein diet.
Clinical Pharmacology and Therapeutics (1988) 43, 681–687; doi:10.1038/clpt.1988.95
Details
- Title: Subtitle
- Renal clearances of oxypurinol and inulin on an isocaloric, low‐protein diet
- Creators
- Therese M Kitt - University of IowaGlen D Park - University of IowaReynold Spector - University of IowaWilliam Lawton - University of IowaEva Tsalikian - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.43(6), pp.681-687
- DOI
- 10.1038/clpt.1988.95
- PMID
- 3378389
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 7
- Grant note
- Burroughs Wellcome Fund and the Pharmaceutical Manufacturers Association Foundation College of Medicine National Institutes of Health General Clinical Research Center Support (RR59)
- Language
- English
- Date published
- 06/1988
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984093472802771
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