Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life

William V Page; Stanley Perlman; Francine G Smith; Jeffrey L Segar; Jean E Robillard

doi:10.1152/ajpregu.1992.262.3.R459

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Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life

Journal article

Peer reviewed

Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life

William V Page, Stanley Perlman, Francine G Smith, Jeffrey L Segar and Jean E Robillard

The American journal of physiology, Vol.262(3 Pt 2), pp.R459-463

03/1992

DOI: 10.1152/ajpregu.1992.262.3.R459

PMID: 1373041

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Abstract

The role of renal nerves in regulating changes in plasma renin activity (PRA) and renal renin gene expression was studied in intact (n = 6) and denervated (n = 6) fetal sheep before birth and during the first 24 h after delivery. Renal denervation completely blunted the rise in PRA observed 24 h after delivery in newborn lambs; in lambs with intact kidneys, PRA increased significantly (P less than 0.05) from 3.26 +/- 0.60 (predelivery) to 6.34 +/- 1.85 ng angiotensin I (ANG I).ml-1.h-1 (24 h postdelivery), while in lambs with denervated kidneys, predelivery and post-delivery values were 2.84 +/- 0.19 and 2.49 +/- 0.45 ng ANG I.ml-1.h-1, respectively. Renin mRNA levels were significantly lower (P less than 0.001) in denervated than in intact kidneys 24 h after birth. A close analysis of these results also revealed that renin mRNA levels were significantly higher (P less than 0.001) in intact kidneys of newborn lambs delivered vaginally (n = 3) than in newborn lambs delivered by cesarean section (n = 3). These results suggest that renal nerves play an important role in regulating renin gene expression and PRA during the transition from fetal to newborn life.

Aging

Gene Expression

Pregnancy

Animals, Newborn

Kidney - physiology

Kidney - embryology

Phosphorus Radioisotopes

Sympathetic Nervous System - embryology

RNA - genetics

Gene Expression Regulation, Enzymologic

Autoradiography

Blotting, Northern

RNA - isolation & purification

Renin - genetics

Animals

Sympathetic Nervous System - physiology

Female

Kidney - innervation

Sheep

Denervation

Details

Title: Subtitle: Renal nerves modulate kidney renin gene expression during the transition from fetal to newborn life
Creators: William V Page - Department of Pediatrics, College of Medicine, University of Iowa, Iowa City 52242
Stanley Perlman
Francine G Smith
Jeffrey L Segar
Jean E Robillard
Resource Type: Journal article
Publication Details: The American journal of physiology, Vol.262(3 Pt 2), pp.R459-463
DOI: 10.1152/ajpregu.1992.262.3.R459
PMID: 1373041
NLM abbreviation: Am J Physiol
ISSN: 0002-9513
eISSN: 2163-5773
Publisher: United States
Grant note: HD-20576 / NICHD NIH HHS HL-14388 / NHLBI NIH HHS DK-38302 / NIDDK NIH HHS
Language: English
Date published: 03/1992
Academic Unit: Microbiology and Immunology; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777349902771

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