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Renal vascular responses to isoproterenol
Journal article   Peer reviewed

Renal vascular responses to isoproterenol

Allyn L Mark, John W Eckstein, Francois Abboud and Michael G Wendling
The American journal of physiology, Vol.217(3), pp.764-767
09/1969
DOI: 10.1152/ajplegacy.1969.217.3.764
PMID: 4980010

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Abstract

Renal vascular responses to isoproterenol were studied in anesthetized dogs to determine whether or not this agent stimulates alpha-adrenergic receptors in the kidney. Isoproterenol, norepinephrine, and nitroglycerin were injected into the renal artery before and after renal arterial infusions of phenoxybenzamine, propranolol, or saline. Renal blood flow and arterial pressure were measured continuously. Before the antagonists, dose-related increases in flow occurred with five doses of isoproterenol. The vasodilator response to isoproterenol was not enhanced by phenoxybenzamine. Propranolol reduced or abolished the vasodilatation with isoproterenol. After propranolol, reversal to vasoconstriction was observed with isoproterenol, 50 and 100 pg, but not with lower doses. The vasoconstriction with the high doses was, in turn, abolished or reversed by phentolamine. These studies suggest that very high doses of isoproterenol stimulate alpha or vasoconstrictor receptors, as well as beta receptors, in the renal circulation of dogs. Only beta-receptor stimulation was seen with lower doses.
 Norepinephrine - pharmacology Animals Kidney - blood supply Kidney - drug effects Regional Blood Flow - drug effects Sensory Receptor Cells - physiology Isoproterenol - pharmacology Dogs Hemodynamics - drug effects Renal Artery - drug effects Nitroglycerin - pharmacology

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