Journal article
Renewed Interest in Chlorthalidone: Evidence From the Veterans Health Administration
The journal of clinical hypertension (Greenwich, Conn.), Vol.12(12), pp.927-934
12/01/2010
DOI: 10.1111/j.1751-7176.2010.00373.x
PMCID: PMC8673312
PMID: 21122058
Abstract
Thiazide-type diuretics are recommended in national hypertension treatment guidelines, but these guidelines do not give preference to a specific thiazide. Recently, increased use of chlorthalidone has been advocated. The authors reviewed national outpatient prescription data from the Veterans Health Administration from 2003 to 2008 to describe the prescribing trends within the thiazide class, focusing on hydrochlorothiazide and chlorthalidone. Among total thiazide users, the proportion who received hydrochlorothiazide remained stable (95.6% in 2008), but the number of new users of hydrochlorothiazide decreased nearly 30% during this period. In contrast, the proportion of chlorthalidone use among total thiazide users more than doubled (1.1% in 2003 to 2.4% in 2008), and the number of new chlorthalidone users increased by more than 40%. At the time of initiation, chlorthalidone was more likely to be added to an existing antihypertensive regimen; one quarter (25.1%) of new hydrochlorothiazide starts were in patients not receiving concurrent antihypertensive medications, compared with only 12.1% for chlorthalidone (odds ratio, 0.44; 95% confidence interval, 0.42-0.46). Evaluation of national prescribing trends indicates that hydrochlorothiazide remains the most commonly prescribed thiazide, but there appears to be a shift toward more new users of chlorthalidone. J Clin Hypertens (Greenwich). 2010;12:927-934. (C) 2010 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Renewed Interest in Chlorthalidone: Evidence From the Veterans Health Administration
- Creators
- Michael E. Ernst - University of IowaBrian C. Lund - Veterans Health Administration
- Resource Type
- Journal article
- Publication Details
- The journal of clinical hypertension (Greenwich, Conn.), Vol.12(12), pp.927-934
- DOI
- 10.1111/j.1751-7176.2010.00373.x
- PMID
- 21122058
- PMCID
- PMC8673312
- NLM abbreviation
- J Clin Hypertens (Greenwich)
- ISSN
- 1524-6175
- eISSN
- 1751-7176
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- Veterans Health Administration; US Department of Veterans Affairs REA 09-220 / Health Services Research and Development Service through the Center for Research in the Implementation of Innovative Strategies in Practice (CRIISP) Department of Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 12/01/2010
- Academic Unit
- Epidemiology; Family and Community Medicine; Pharmacy Practice and Science
- Record Identifier
- 9984297336902771
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