Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic

Giuseppe De Luca; Matteo Nardin; Magdy Algowhary; Berat Uguz; Dinaldo C. Oliveira; Vladimir Ganyukov; Zan Zimbakov; Miha Cercek; Lisette Okkels Jensen; Poay Huan Loh; Lucian Calmac; Gerard Roura Ferrer; Alexandre Quadros; Marek Milewski; Fortunato Scotto di Uccio; Clemens von Birgelen; Francesco Versaci; Jurrien Ten Berg; Gianni Casella; Aaron Wong Sung Lung; Petr Kala; Jose Luis Diez Gil; Xavier Carrillo; Maurits Dirksen; Victor M. Becerra-Munoz; Michael Kang-yin Lee; Dafsah Arifa Juzar; Rodrigo de Moura Joaquim; Roberto Paladino; Davor Milicic; Periklis Davlouros; Nikola Bakraceski; Filippo Zilio; Luca Donazzan; Adriaan Kraaijeveld; Gennaro Galasso; Arpad Lux; Lucia Marinucci; Vincenzo Guiducci; Maurizio Menichelli; Alessandra Scoccia; Aylin Hatice Yamac; Kadir Ugur Mert; Xacobe Flores Rios; Tomas Kovarnik; Michal Kidawa; Jose Moreu; Vincent Flavien; Enrico Fabris; Inigo Lozano Martinez-Luengas; Marco Boccalatte; Francisco Bosa Ojeda; Carlos Arellano-Serrano; Gianluca Caiazzo; Giuseppe Cirrincione; Hsien-Li Kao; Juan Sanchis Fores; Luigi Vignali; Helder Pereira; Stephane Manzo; Santiago Ordonez; Alev Arat Ozkan; Bruno Scheller; Heidi Lehtola; Rui Teles; Christos Mantis; Ylitalo Antti; Joao Antonio Brum Silveira; Rodrigo Zoni; Ivan Bessonov; Stefano Savonitto; George Kochiadakis; Dimitrios Alexopulos; Carlos E. Uribe; John Kanakaki; Benjamin Faurie; Gabriele Gabrielli; Alejandro Gutierrez Barrios; Juan Pablo Bachini; Alex Rocha; Frankie Chor-Cheung Tam; Alfredo Rodriguez; Antonia Anna Lukito; Veauthyelau Saint-Joy; Gustavo Pessah; Andrea Tuccillo; Giuliana Cortese; Guido Parodi; Mohammed Abed Bouraghda; Elvin Kedhi; Pablo Lamelas; Harry Suryapranata; Monica Verdoia

doi:10.1016/j.deman.2021.100022

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Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic

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Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic

Giuseppe De Luca, Matteo Nardin, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, …

Diabetes epidemiology and management, Vol.4, pp.100022-100022

10/01/2021

DOI: 10.1016/j.deman.2021.100022

PMCID: PMC8556094

PMID: 35072135

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Abstract

Background: During the coronavirus disease 2019 (COVID-19) pandemic, concerns have been arisen on the use of renin-angiotensin system inhibitors (RASI) due to the potentially increased expression of Angiotensin-converting-enzyme (ACE)2 and patient's susceptibility to SARS-CoV2 infection. Diabetes mellitus have been recognized favoring the coronavirus infection with consequent increase mortality in COVID-19. No data have been so far reported in diabetic patients suffering from ST-elevation myocardial infarction (STEMI), a very high-risk population deserving of RASI treatment.Methods: The ISACS-STEMI COVID-19 registry retrospectively assessed STEMI patients treated with primary percutaneous coronary intervention (PPCI) in March/June 2019 and 2020 in 109 European high-volume pri-mary PCI centers. This subanalysis assessed the prognostic impact of chronic RASI therapy at admission on mortality and SARS-CoV2 infection among diabetic patients.Results: Our population is represented by 3812 diabetic STEMI patients undergoing mechanical reperfusion, 2038 in 2019 and 1774 in 2020. Among 3761 patients with available data on chronic RASI therapy, between those ones with and without treatment there were several differences in baseline characteristics, (similar in both periods) but no difference in the prevalence of SARS-CoV2 infection (1.6% vs 1.3%, respectively, p = 0.786). Considering in-hospital medication, RASI therapy was overall associated with a significantly lower in-hospital mortality (3.3% vs 15.8%, p < 0.0001), consistently both in 2019 and in 2010.Conclusions: This is first study to investigate the impact of RASI therapy on prognosis and SARS-CoV2 infec-tion of diabetic patients experiencing STEMI and undergoing PPCI during the COVID-19 pandemic. Both pre-admission chronic RASI therapy and in-hospital RASI did not negatively affected patients' survival during the hospitalization, neither increased the risk of SARS-CoV2 infection. Trial registration number: NCT 04412655 (c) 2021 Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Endocrinology & Metabolism

Life Sciences & Biomedicine

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Title: Subtitle: Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic
Creators: Giuseppe De Luca - Azienda Ospedaliero Universitaria Maggiore della Carita
Matteo Nardin - Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Magdy Algowhary - Assiut University
Berat Uguz - Bursa Technical University
Dinaldo C. Oliveira - Univ Fed Pernambuco, Ctr PROCAPE, Pronto Socorro Cardiol Prof Luis Tavares, Recife, PE, Brazil
Vladimir Ganyukov - Kemerovo State University
Zan Zimbakov - Saints Cyril and Methodius University of Skopje
Miha Cercek - Ljubljana University Medical Centre
Lisette Okkels Jensen - Odense University Hospital
Poay Huan Loh - National University Hospital
Lucian Calmac - Clinical Emergency Hospital Bucharest
Gerard Roura Ferrer - Bellvitge University Hospital
Alexandre Quadros - Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, Brazil
Marek Milewski - Medical University of Silesia
Fortunato Scotto di Uccio - Osped Mare, Div Cardiol, Naples, Italy
Clemens von Birgelen - Medisch Spectrum Twente
Francesco Versaci - Ospedale Santa Maria Goretti
Jurrien Ten Berg - St Antonius Hosp, Div Cardiol, Nieuwegein, Netherlands
Gianni Casella - Ospedale Maggiore
Aaron Wong Sung Lung - National Heart Centre Singapore
Petr Kala - Masaryk University
Jose Luis Diez Gil - Univ & Politecn La Fe, Valencia, Spain
Xavier Carrillo - Hosp Germans Triasi Pujol, Badalona, Spain
Maurits Dirksen - Northwest Clin Alkmaar, Div Cardiol, Alkmaar, Netherlands
Victor M. Becerra-Munoz - Hosp Clin Univ Virgen de la Victoria, Malaga, Spain
Michael Kang-yin Lee - University of Hong Kong
Dafsah Arifa Juzar - University of Indonesia
Rodrigo de Moura Joaquim - Inst Cardiol Santa Catarina Praia Comprida, Sao Jose, Brazil
Roberto Paladino - Clin Villa dei Fiori, Div Cardiol, Acerra, Italy
Davor Milicic - University of Zagreb
Periklis Davlouros - Patras Univ Hosp, Invas Cardiol & Congenital Heart Dis, Patras, Greece
Nikola Bakraceski - Ctr Cardiovasc Dis, Ohrid, North Macedonia
Filippo Zilio - Osped Santa Chiara Trento, Div Cardiol, Trento, Italy
Luca Donazzan - Azienda Ospedaliero Universitaria Maggiore della Carita
Adriaan Kraaijeveld - University Medical Center Utrecht
Gennaro Galasso - Osped San Giovanni di Dio & Ruggi dAragona, Div Cardiol, Salerno, Italy
Arpad Lux - Maastricht University
Lucia Marinucci - Clinical Emergency Hospital Bucharest
Vincenzo Guiducci - AUSL IRCCS Reggio Emilia, Div Cardiol, Reggio Emilia, Italy
Maurizio Menichelli - Osped F Spaziani, Div Cardiol, Frosinone, Italy
Alessandra Scoccia - Osped St Anna, Div Cardiol, Ferrara, Italy
Aylin Hatice Yamac - Hosp Bezmialem Vakif Univ, Dept Cardiol, Istanbul, Turkey
Kadir Ugur Mert - Eskişehir Osmangazi University
Xacobe Flores Rios - Complexo Hosp Univ La Coruna, La Coruna, Spain
Tomas Kovarnik - Univ Hosp Prague, Prague, Czech Republic
Michal Kidawa - Med Univ Lodz, Cent Hosp, Lodz, Poland
Jose Moreu - ComplejoHosp Toledo, Div Cardiol, Toledo, Spain
Vincent Flavien - Ctr Hosp Univ Lille, Div Cardiol, Lille, France
Enrico Fabris - Azienda Osped Univ Osped Riuniti Trieste, Trieste, Italy
Inigo Lozano Martinez-Luengas - Hosp Cabuenes, Div Cardiol, Gijon, Spain
Marco Boccalatte - Osped Santa Maria delle Grazie, Div Cardiol, Pozzuoli, Italy
Francisco Bosa Ojeda - Hosp Univ Canarias, Div Cardiol, Santa Cruz De Tenerife, Spain
Carlos Arellano-Serrano - Hosp Puerta de Hierro Majadahonda, Div Cardiol, Madrid, Spain
Gianluca Caiazzo - Osped G Moscati, Div Cardiol, Aversa, Italy
Giuseppe Cirrincione - Azienda Ospedaliero Universitaria Maggiore della Carita
Hsien-Li Kao - Natl Taiwan Univ Hosp, Cardiol Div, Dept Internal Med, Taipei, Taiwan
Juan Sanchis Fores - Hosp Clin Univ Valencia, Div Cardiol, Valencia, Spain
Luigi Vignali - Azienda Osped Sanitaria, Intervent Cardiol Unit, Parma, Italy
Helder Pereira - Hosp Garcia de Orta, Cardiol Dept, Almada, HP, Portugal
Stephane Manzo - Assistance Publique – Hôpitaux de Paris
Santiago Ordonez - Inst Cardiovasc Buenos Aires, Buenos Aires, DF, Argentina
Alev Arat Ozkan - Instanbul Univ, Cardiol Inst, Istanbul, Turkey
Bruno Scheller - Univ Saarland, Div Cardiol Clin & Expt Intervent Cardiol, Saarbrucken, Germany
Heidi Lehtola - Oulu Univ Hosp, Div Cardiol, Oulu, Finland
Rui Teles - Nova Southeastern University
Christos Mantis - Kontantopoul Hosp, Div Cardiol, Athens, Greece
Ylitalo Antti - Heart Ctr Turku, Div Cardiol, Turku, Finland
Joao Antonio Brum Silveira - Hosp Santo Antonio, Div Cardiol, Porto, Portugal
Rodrigo Zoni - Inst Cardiol Corrientes, Dept Teaching & Res, Corrientes, Argentina
Ivan Bessonov - Tyumen Cardiol Res Ctr, Tyumen, Russia
Stefano Savonitto - Osped A Manzoni, Div Cardiol, Lecce, Italy
George Kochiadakis - Iraklion Univ Hosp, Iraklion, Greece
Dimitrios Alexopulos - Attikon Univ Hosp, Div Cardiol, Athens, Greece
Carlos E. Uribe - Universidad CES
John Kanakaki - Alexandra Hosp, Div Cardiol, Athens, Greece
Benjamin Faurie - Grp Hosp Mutualiste Grenoble, Div Cardiol, Grenoble, France
Gabriele Gabrielli - Azienda Osped Univ Osped Riuniti, Intervent Cardiol Unit, Ancona, Italy
Alejandro Gutierrez Barrios - Hosp Puerta del Mar, Div Cardiol, Cadiz, Spain
Juan Pablo Bachini - Inst Cardiol Integral, Montevideo, Uruguay
Alex Rocha - Fundação Universitária de Cardiologia
Frankie Chor-Cheung Tam - University of Hong Kong
Alfredo Rodriguez - Otamendi Hosp, Div Cardiol, Buenos Aires, DF, Argentina
Antonia Anna Lukito - Pelita Harapan University
Veauthyelau Saint-Joy - Ctr Hosp Antibes Juan Les Pins, Antibes, France
Gustavo Pessah - Hospiatl Cordoba, Div Cardiol, Cordoba, Argentina
Andrea Tuccillo - Osped Mare, Div Cardiol, Naples, Italy
Giuliana Cortese - University of Padua
Guido Parodi - University of Sassari
Mohammed Abed Bouraghda - Blida Univ Hosp, Div Cardiol, Blida, Algeria
Elvin Kedhi - Univ Libre Bruxelles, Div Cardiol, Hop Erasmus, Brussels, Belgium
Pablo Lamelas - Radboud University Nijmegen
Harry Suryapranata - ASL, Div Cardiol, Osped Infermi, Biella, Italy
Monica Verdoia - ASL, Div Cardiol, Osped Infermi, Biella, Italy
Resource Type: Journal article
Publication Details: Diabetes epidemiology and management, Vol.4, pp.100022-100022
Publisher: Elsevier
DOI: 10.1016/j.deman.2021.100022
PMID: 35072135
PMCID: PMC8556094
ISSN: 2666-9706
eISSN: 2666-9706
Number of pages: 9
Language: English
Date published: 10/01/2021
Academic Unit: Electrical and Computer Engineering
Record Identifier: 9984627192402771

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