Journal article
Repair of DNA Breaks by Break-Induced Replication
Annual review of biochemistry, Vol.90(1), pp.165-191
06/20/2021
DOI: 10.1146/annurev-biochem-081420-095551
PMCID: PMC9629446
PMID: 33792375
Abstract
Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One such pathway is break-induced replication (BIR), which repairs primarily one-ended DSBs, similar to those formed by collapsed replication forks or telomere erosion. BIR is initiated by the invasion of a broken DNA end into a homologous template, synthesizes new DNA within the context of a migrating bubble, and is associated with conservative inheritance of new genetic material. This mode of synthesis is responsible for a high level of genetic instability associated with BIR. Eukaryotic BIR was initially investigated in yeast, but now it is also actively studied in mammalian systems. Additionally, a significant breakthrough has been made regarding the role of microhomology-mediated BIR in the formation of complex genomic rearrangements that underly various human pathologies.
Details
- Title: Subtitle
- Repair of DNA Breaks by Break-Induced Replication
- Creators
- Z W Kockler - Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.eduB Osia - Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.eduR Lee - Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.eduK Musmaker - Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.eduA Malkova - Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA; email: anna-malkova@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Annual review of biochemistry, Vol.90(1), pp.165-191
- DOI
- 10.1146/annurev-biochem-081420-095551
- PMID
- 33792375
- PMCID
- PMC9629446
- NLM abbreviation
- Annu Rev Biochem
- ISSN
- 0066-4154
- eISSN
- 1545-4509
- Grant note
- R35 GM127006 / NIGMS NIH HHS
- Language
- English
- Date published
- 06/20/2021
- Academic Unit
- Biology
- Record Identifier
- 9984217528902771
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