Journal article
Repair of craniofacial defects with hydroxyapatite cement
Journal of oral and maxillofacial surgery, Vol.55(12), pp.1441-1449
1997
DOI: 10.1016/S0278-2391(97)90647-9
PMID: 9393404
Abstract
Purpose:
The objective of this study was to evaluate the course of healing of craniofacial bone defects when filled with hydroxyapatite cement and to determine whether adding various percentages by weight of demineralized bone powder to the cement will result in enhanced bone formation.
Materials and Methods:
The model for the study was the canine calvarium. The implants were placed into cranial defects and harvested at 3 or 6 months for qualitative evaluation by light microscopy, microradiography, and quantitative histomorphometry.
Results:
The implantation of hydroxyapatite cement resulted in characteristic replacement of the material with new bone ingrowth. The addition of demineralized bone powder to the hydroxyapatite cement appeared to improve the handling characteristics of the cement; however, improvement in the replacement of the material by bone was not observed. The implantation of only allogeneic demineralized bone showed limited new bone formation within the defect site.
Conclusions:
Hydroxyapatite cement formed an effective osseoconductive scaffold for bone replacement. The addition of demineralized bone powder to the cement to serve as a carrier of osseoinductive factors did not result in additional bone being formed.
Details
- Title: Subtitle
- Repair of craniofacial defects with hydroxyapatite cement
- Creators
- Daniel Lew - Department of Oral and Maxillofacial Surgery, University of Iowa Hospitals and Clinics USABrian FarrellJanusz Bardach - Department of Otolaryngology, University of Iowa Hospitals and Clinics USAJohn Keller - Department of Oral and Maxillofacial Surgery and Dows, Institute for Dental Research, College of Dentistry USA
- Resource Type
- Journal article
- Publication Details
- Journal of oral and maxillofacial surgery, Vol.55(12), pp.1441-1449
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0278-2391(97)90647-9
- PMID
- 9393404
- ISSN
- 0278-2391
- eISSN
- 1531-5053
- Language
- English
- Date published
- 1997
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Graduate College Admin and Gen; President; Oral and Maxillofacial Surgery; Dental Research
- Record Identifier
- 9984065700402771
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