Repatriation is associated with isthmus cingulate cortex reduction in community-dwelling elderly

Raffaella Calati; Jerome J Maller; Chantal Meslin; Jorge Lopez-Castroman; Karen Ritchie; Philippe Courtet; Sylvaine Artero

doi:10.1080/15622975.2016.1258490

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Repatriation is associated with isthmus cingulate cortex reduction in community-dwelling elderly

Journal article

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Repatriation is associated with isthmus cingulate cortex reduction in community-dwelling elderly

Raffaella Calati, Jerome J Maller, Chantal Meslin, Jorge Lopez-Castroman, Karen Ritchie, Philippe Courtet and Sylvaine Artero

The world journal of biological psychiatry, Vol.19(6), pp.421-430

08/18/2018

DOI: 10.1080/15622975.2016.1258490

PMID: 27844618

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https://openresearch-repository.anu.edu.au/bitstreams/a6d4f55c-78ee-4a4c-8d29-8d12aeae7a90/downloadView

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Abstract

Objectives: The impact of stressful life events (SLEs) on brain anatomy is poorly understood, particularly its long-term neural consequences. We tested the hypothesis that a serious SLE (repatriation of French citizens living in Algeria in 1962) is associated with changes in brain regions previously implicated in psychopathology (hippocampus, amygdala, corpus callosum, prefrontal cortex, anterior, posterior and isthmus cingulate cortex (ICC)) in a large elderly population. Methods: Structural magnetic resonance imaging was used to acquire anatomical scans from 82 subjects repatriated from Algeria and 339 subjects without this experience or any other trauma. We derived quantitative regional estimates of subcortical volume using FreeSurfer Software. The General Linear Model was used to test the association between repatriation and changes in brain volume adjusted for confounders (gender, age, education, total brain volume, traumatic brain injury, Mini Mental State Examination score at baseline, current and lifetime major depression and recent SLEs). Results: Repatriation to France was associated with reduced volume in a number of areas; however, only left and right ICC survived to false discovery rate correction. Conclusions: In the elderly a previous (approximately 40 years before) serious SLE could be associated with long-term volume reduction in the ICC, independently of psychopathology.

Details

Title: Subtitle: Repatriation is associated with isthmus cingulate cortex reduction in community-dwelling elderly
Creators: Raffaella Calati - Centre Hospitalier Universitaire de Montpellier
Jerome J Maller - Monash Alfred Psychiatry Research centre
Chantal Meslin - Australian National University
Jorge Lopez-Castroman - Inserm
Karen Ritchie - Centre Hospitalier Universitaire de Montpellier
Philippe Courtet - Centre Hospitalier Universitaire de Montpellier
Sylvaine Artero - Centre Hospitalier Universitaire de Montpellier
Resource Type: Journal article
Publication Details: The world journal of biological psychiatry, Vol.19(6), pp.421-430
DOI: 10.1080/15622975.2016.1258490
PMID: 27844618
NLM abbreviation: World J Biol Psychiatry
ISSN: 1562-2975
eISSN: 1814-1412
Number of pages: 10
Language: English
Date published: 08/18/2018
Academic Unit: Radiology
Record Identifier: 9984848510602771

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