Repeatability of Gallium-68 DOTATOC Positron Emission Tomographic Imaging in Neuroendocrine Tumors

Yusuf Menda; Laura L. Boles Ponto; Michael K Schultz; Gideon K.D Zamba; G. Leonard Watkins; David L Bushnell; Mark T Madsen; John J Sunderland; Michael M Graham; Thomas M O’Dorisio; M. Sue O’Dorisio

doi:10.1097/MPA.0b013e318287ce21

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Repeatability of Gallium-68 DOTATOC Positron Emission Tomographic Imaging in Neuroendocrine Tumors

Journal article

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Repeatability of Gallium-68 DOTATOC Positron Emission Tomographic Imaging in Neuroendocrine Tumors

Yusuf Menda, Laura L. Boles Ponto, Michael K Schultz, Gideon K.D Zamba, G. Leonard Watkins, David L Bushnell, Mark T Madsen, John J Sunderland, Michael M Graham, Thomas M O’Dorisio, …

Pancreas, Vol.42(6), pp.937-943

08/2013

DOI: 10.1097/MPA.0b013e318287ce21

PMID: 23587853

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Abstract

Objective To evaluate the repeatability of gallium-68 1,4,7,10-tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetic (DOTA)-D-Phe1-Try3-octreotide (68Ga-DOTATOC) positron emission tomography (PET) in neuroendocrine tumors. Methods Five patients with neuroendocrine tumors were imaged with 68Ga-DOTATOC PET twice within 5 days. Maximum and mean standardized uptake values (SUVmax and SUVmean) and kinetic parameters (K-Patlak and K-influx) of target lesions were measured. The repeatability of these measurements was investigated. Results Forty-seven target lesions were identified on whole-body PET and 21 lesions on dynamic images. There was excellent repeatability with intraclass correlation coefficient of 0.99 for SUVmax, SUVmean, and K-Patlak, and 0.85 for K-influx. The median absolute percent differences and the interquartile ranges (IQR) between 2 scans for SUVmax and SUVmean were 7.4% (IQR, 14.1%) and 9.3% (IQR, 10.6%), respectively. The median absolute percent differences for K-Patlak and K-influx were 12.5% (IQR, 12.6%) and 29.9% (IQR, 22.4%), respectively. The SUVmax of target lesions did not differ by more than 25% between the 2 scans. Conclusions 68Ga-DOTATOC PET imaging of neuroendocrine tumors is highly reproducible. A difference of more than 25% in SUVmax represents a change that is larger than the measurement error observed on repeated studies and should reflect a significant change in the biological character of the tumor.

Details

Title: Subtitle: Repeatability of Gallium-68 DOTATOC Positron Emission Tomographic Imaging in Neuroendocrine Tumors
Creators: Yusuf Menda
Laura L. Boles Ponto
Michael K Schultz
Gideon K.D Zamba
G. Leonard Watkins
David L Bushnell
Mark T Madsen
John J Sunderland
Michael M Graham
Thomas M O’Dorisio
M. Sue O’Dorisio
Resource Type: Journal article
Publication Details: Pancreas, Vol.42(6), pp.937-943
DOI: 10.1097/MPA.0b013e318287ce21
PMID: 23587853
NLM abbreviation: Pancreas
ISSN: 0885-3177
eISSN: 1536-4828
Language: English
Date published: 08/2013
Academic Unit: Radiology; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Physics and Astronomy; Radiation Oncology; Internal Medicine
Record Identifier: 9983997438302771

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