Journal article
Repeated ingestion of aspartame-sweetened beverage: Effect on plasma amino acid concentrations in individuals heterozygous for phenylketonuria
Metabolism, clinical and experimental, Vol.38(1), pp.78-84
1989
DOI: 10.1016/0026-0495(89)90184-4
PMID: 2909831
Abstract
It has been suggested that excessive use of aspartame (APM) (N-
l-α-aspartyl-
l-phenylalanine methyl ester) might grossly elevate plasma aspartate and phenylalanine concentrations in individuals heterozygous for phenylketonuria (PKUH). In study 1 six adult PKUH (three males; three females) ingested three successive 12-oz servings of beverage at 2-h intervals. The study was carried out in two parts in a randomized crossover design. In one arm the beverage was not sweetened. In the other the beverage provided 10 mg AMP/kg body weight per serving. The addition of APM to the beverage did not significantly increase plasma aspartate concentration but did increase plasma phenylalanine levels 2.3 to 4.1 μmol/dL above baseline values 30 to 45 min after each dose. The high mean plasma phenylalanine level after repeated APM dosing (13.9 ± 2.15 μmol/dL) was slightly, but not significantly, above the normal postprandial range for PKUH (12.6 ± 2.11 μmol/dL). In study 2 six different adult PKUH ingested beverage providing 30 mg APM/kg body weight as a single bolus. The high mean plasma phenylalanine concentration and the phenylalanine to large neutral amino acid ratio were significantly higher when APM was ingested as a single bolus than when ingested as a divided dose.
Details
- Title: Subtitle
- Repeated ingestion of aspartame-sweetened beverage: Effect on plasma amino acid concentrations in individuals heterozygous for phenylketonuria
- Creators
- Lewis D Stegink - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USAL.J Filer - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USAGeorge L Baker - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USAEdward F Bell - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USAEkhard E Ziegler - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USAMarvin C Brummel - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USAWilma L Krause - Department of Pediatrics, University of Iowa College of Medicine, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Metabolism, clinical and experimental, Vol.38(1), pp.78-84
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0026-0495(89)90184-4
- PMID
- 2909831
- ISSN
- 0026-0495
- eISSN
- 1532-8600
- Language
- English
- Date published
- 1989
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984093465702771
Metrics
23 Record Views