Repeated light-dark shifts speed up body weight gain in male F344 rats

Ling-Ling Tsai; Yu-Che Tsai; Kai Hwang; Yu-Wen Huang; Jeh-En Tzeng

doi:10.1152/ajpendo.00603.2004

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Repeated light-dark shifts speed up body weight gain in male F344 rats

Journal article

Open access

Peer reviewed

Repeated light-dark shifts speed up body weight gain in male F344 rats

Ling-Ling Tsai, Yu-Che Tsai, Kai Hwang, Yu-Wen Huang and Jeh-En Tzeng

American journal of physiology: endocrinology and metabolism, Vol.289(2), pp.E212-E217

08/2005

DOI: 10.1152/ajpendo.00603.2004

PMID: 15741238

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Abstract

This study is aimed at verifying the causal relationship of chronic circadian desynchronization and changes in body weight control. Eight male albino F344 rats aged between 12-15 wk were subjected to twice weekly 12-h shifts of the daily light-dark (LD) cycle for 13 wk (3 mo). Continuous circadian phase shifts consisting of intermittent phase delay and advance and reduced circadian amplitudes were consistently displayed in all five experimental rats implanted intraperitoneally with heart rate, body temperature, and activity transponders. The experimental rat maintained a greater body weight during LD shifts and even after 10 days of recovery than that of the age-matched control rat, which was maintained on a regular LD cycle. Body weight gain was greater in the first 2 mo of LD shifts in the experimental rat than in the control rat. Relative to the baseline, food intake and activity percentages were increased and reduced, respectively, for the experimental rats. Features of these results, such as increased body weight gain and food intake, and reduced activity, suggest a causal relationship of chronic circadian desynchronization and changes in body weight control in male albino F344 rats.

Body Temperature - radiation effects

Darkness

Heart Rate - radiation effects

Motor Activity - physiology

Rats, Inbred F344

Rats

Male

Weight Gain - physiology

Circadian Rhythm - physiology

Photoperiod

Body Temperature - physiology

Eating - radiation effects

Eating - physiology

Motor Activity - radiation effects

Animals

Analysis of Variance

Weight Gain - radiation effects

Light

Energy Metabolism - radiation effects

Heart Rate - physiology

Circadian Rhythm - radiation effects

Energy Metabolism - physiology

Details

Title: Subtitle: Repeated light-dark shifts speed up body weight gain in male F344 rats
Creators: Ling-Ling Tsai - Dept. of Psychology, National Chung-Cheng Univ., 168 University Road, Min-Hsiung, Chia-yi 621, Taiwan, R.O.C. psyllt@ccu.edu.tw
Yu-Che Tsai
Kai Hwang
Yu-Wen Huang
Jeh-En Tzeng
Resource Type: Journal article
Publication Details: American journal of physiology: endocrinology and metabolism, Vol.289(2), pp.E212-E217
DOI: 10.1152/ajpendo.00603.2004
PMID: 15741238
NLM abbreviation: Am J Physiol Endocrinol Metab
ISSN: 0193-1849
eISSN: 1522-1555
Publisher: United States
Language: English
Date published: 08/2005
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984001104802771

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