Repercussão da hipertensão arterial na regeneração hepática em ratos

Maria de Lourdes Pessole Biondo-Simões; Camila Gadens Zamboni; Evelise Martins; Luka David Lechinewski; Sérgio Ossamu Ioshii; Rogerio Ribeiro Robes

doi:10.1590/S0102-86502012000700005

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Repercussão da hipertensão arterial na regeneração hepática em ratos

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Repercussão da hipertensão arterial na regeneração hepática em ratos

Maria de Lourdes Pessole Biondo-Simões, Camila Gadens Zamboni, Evelise Martins, Luka David Lechinewski, Sérgio Ossamu Ioshii and Rogerio Ribeiro Robes

Acta cirúrgica brasileira, Vol.27(7), pp.460-464

07/2012

DOI: 10.1590/S0102-86502012000700005

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Abstract

PURPOSE: To determine the impact of hypertension in liver regeneration, in rats by examining gain in liver mass and the replication of hepatocytes and stellate cells. METHODS: Forty Wistar rats were allocated into two groups of twenty, the control and experiment group. The experiment group animals were submitted to induction of renovascular hypertension. A week later, all the animals underwent a partial hepatectomy. Measurements were taken after 24 hours and seven days, when ten animals in each group were euthanized. Thus, four subgroups were obtained. The livers were excised and sent for histopathological analysis. RESULTS: The control group had a greater gain in liver mass than the experiment group seven days after partial hepatectomy (p=0.0051). The difference in the activate stellate cell count was not statistically significant following analysis after both 24 hours and seven days (p=1.0). A higher number of dividing hepatocytes was observed in the control group seven days after partial hepatectomy (p=0.0014). CONCLUSION: In rats, hypertension had no direct influence on stellate cell replication, but led to a delay in liver mass gain and were shown to be a reduction factor on hepatocyte replication seven7 days after partial hepatectomy.

Hypertension

Liver Regeneration

Rats

Details

Title: Subtitle: Repercussão da hipertensão arterial na regeneração hepática em ratos
Creators: Maria de Lourdes Pessole Biondo-Simões - Department of Surgery, UFPR, Brazil
Camila Gadens Zamboni - Universidade Federal do Paraná
Evelise Martins - Universidade Federal do Paraná
Luka David Lechinewski - Universidade Federal do Paraná
Sérgio Ossamu Ioshii - Pontifical Catholic University of Puerto Rico
Rogerio Ribeiro Robes - Universidade Federal do Paraná
Resource Type: Journal article
Publication Details: Acta cirúrgica brasileira, Vol.27(7), pp.460-464
DOI: 10.1590/S0102-86502012000700005
ISSN: 0102-8650
eISSN: 1678-2674
Translated title: Impact of hypertension in liver regeneration in rats
Language: Portuguese
Date published: 07/2012
Academic Unit: Radiology
Record Identifier: 9985179680302771

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