Journal article
Replication and meta-analysis of TMEM132D gene variants in panic disorder
Translational psychiatry, Vol.2(9), pp.e156-e156
09/2012
DOI: 10.1038/tp.2012.85
PMCID: PMC3565207
PMID: 22948381
Abstract
A recent genome-wide association study in patients with panic disorder (PD) identified a risk haplotype consisting of two single-nucleotide polymorphisms (SNPs) (rs7309727 and rs11060369) located in intron 3 of
TMEM132D
to be associated with PD in three independent samples. Now we report a subsequent confirmation study using five additional PD case–control samples (
n
=1670 cases and
n
=2266 controls) assembled as part of the Panic Disorder International Consortium (PanIC) study for a total of 2678 cases and 3262 controls in the analysis. In the new independent samples of European ancestry (EA), the association of rs7309727 and the risk haplotype rs7309727–rs11060369 was, indeed, replicated, with the strongest signal coming from patients with primary PD, that is, patients without major psychiatric comorbidities (
n
=1038 cases and
n
=2411 controls). This finding was paralleled by the results of the meta-analysis across all samples, in which the risk haplotype and rs7309727 reached
P
-levels of
P
=1.4e−8 and
P
=1.1e−8, respectively, when restricting the samples to individuals of EA with primary PD. In the Japanese sample no associations with PD could be found. The present results support the initial finding that
TMEM132D
gene contributes to genetic susceptibility for PD in individuals of EA. Our results also indicate that patient ascertainment and genetic background could be important sources of heterogeneity modifying this association signal in different populations.
Details
- Title: Subtitle
- Replication and meta-analysis of TMEM132D gene variants in panic disorder
- Creators
- A Erhardt - Max-Planck-Institute of PsychiatryN Akula - Human Genetics Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human ServicesJ Schumacher - Institute for Human Genetics, University of BonnD Czamara - Max-Planck-Institute of PsychiatryN Karbalai - Max-Planck-Institute of PsychiatryB Müller-Myhsok - Max-Planck-Institute of PsychiatryO Mors - Department of Psychiatry, Aarhus UniversityA Borglum - Department of Biomedicine, Human Genetics, Aarhus UniversityA S Kristensen - Department of Psychiatry, Aarhus UniversityD P D Woldbye - Department of Neuroscience and Pharmacology, University of CopenhagenP Koefoed - Department of Neuroscience and Pharmacology, University of CopenhagenE Eriksson - University of GothenburgE Maron - University of TartuA Metspalu - Estonian Genome Center, Institute of Molecular and Cell Biology, University of TartuJ Nurnberger - Department of Psychiatry, Indiana UniversityR A Philibert - Behavioural Genetics, University of IowaJ Kennedy - University of TorontoK Domschke - Department of Psychiatry, University of WürzburgA Reif - Department of Psychiatry, University of WürzburgJ Deckert - Department of Psychiatry, University of WürzburgT Otowa - Department of Neuropsychiatry, Graduate School of Medicine, University of TokyoY Kawamura - Research Center for Panic Disorder, Nagoya Mental ClinicH Kaiya - Research Center for PanIC DisorderY Okazaki - Department of Neurology, Tokyo Metropolitan Matsuzawa HospitalH Tanii - Department of Neuropsychiatry, Graduate School of Medicine, Mie UniversityK Tokunaga - Department of Human Genetics, Graduate School of Medicine, University of TokyoT Sasaki - Laboratory of Health Education, Graduate School of Education, University of TokyoJ P A Ioannidis - Stanford Prevention Research Center, Departments of Medicine, Health Research and Policy, and Statistics, Stanford UniversityF J McMahon - Human Genetics Branch, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Department of Health and Human ServicesE B Binder - Max-Planck-Institute of Psychiatry
- Resource Type
- Journal article
- Publication Details
- Translational psychiatry, Vol.2(9), pp.e156-e156
- DOI
- 10.1038/tp.2012.85
- PMID
- 22948381
- PMCID
- PMC3565207
- NLM abbreviation
- Transl Psychiatry
- ISSN
- 2158-3188
- eISSN
- 2158-3188
- Publisher
- Nature Publishing Group
- Alternative title
- TMEM132D gene variants in panic disorder
- Language
- English
- Date published
- 09/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003437002771
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