Journal article
Replication of HIV-1 in primary monocyte cultures
Virology (New York, N.Y.), Vol.175(2), pp.465-476
1990
DOI: 10.1016/0042-6822(90)90431-P
PMID: 2183468
Abstract
A subpopulation of human monocytes began to express surface CD4 during its
in vitro cultivation in the presence of recombinant M-CSF and became susceptible to infection with an isolate of HIV-1 [AD-87(M)], originally recovered from a seropositive individual by cocultivation with primary monocytes. Approximately 10% of the adherent cells synthesized CD4; a similar fraction was infectable with AD-87(M) and produced high levels of progeny particles. An interesting feature of the HIV-1 infection of primary monocytes was the detection of gpl60/120 inside but not on the surface of virus-producing cells. The implication of these results on HIV infection
in vivo will be discussed.
Details
- Title: Subtitle
- Replication of HIV-1 in primary monocyte cultures
- Creators
- Barbara J PottsWendy MauryMalcolm A Martin
- Resource Type
- Journal article
- Publication Details
- Virology (New York, N.Y.), Vol.175(2), pp.465-476
- DOI
- 10.1016/0042-6822(90)90431-P
- PMID
- 2183468
- NLM abbreviation
- Virology
- ISSN
- 0042-6822
- eISSN
- 1096-0341
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1990
- Academic Unit
- Microbiology and Immunology
- Record Identifier
- 9984083205002771
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