Replication of a genome-wide association study of birth weight in preterm neonates

Kelli K Ryckman; Bjarke Feenstra; John R Shaffer; Elise N A Bream; Frank Geller; Eleanor Feingold; Daniel E Weeks; Enrique Gadow; Viviana Cosentino; Cesar Saleme; Hyagriv N Simhan; David Merrill; Chin-To Fong; Tamara Busch; Susan K Berends; Belen Comas; Jorge L Camelo; Heather Boyd; Cathy C Laurie; David Crosslin; Kimberly F Doheny; Elizabeth Pugh; Mads Melbye; Mary L Marazita; John M Dagle; Qi Zhang; Jeffrey C Murray

doi:10.1016/j.jpeds.2011.07.038

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Replication of a genome-wide association study of birth weight in preterm neonates

Journal article

Open access

Peer reviewed

Replication of a genome-wide association study of birth weight in preterm neonates

Kelli K Ryckman, Bjarke Feenstra, John R Shaffer, Elise N A Bream, Frank Geller, Eleanor Feingold, Daniel E Weeks, Enrique Gadow, Viviana Cosentino, Cesar Saleme, …

The Journal of pediatrics, Vol.160(1), pp.19-24.e4

01/2012

DOI: 10.1016/j.jpeds.2011.07.038

PMCID: PMC3237813

PMID: 21885063

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Abstract

To examine associations between rs9883204 in ADCY5 and rs900400 near LEKR1 and CCNL1 with birth weight in a preterm population. Both markers were associated with birth weight in a term population in a recent genome-wide association study of Freathy et al. A meta-analysis of mother and infant samples was performed for associations of rs900400 and rs9883204 with birth weight in 393 families from the US, 265 families from Argentina, and 735 mother-infant pairs from Denmark. Z-scores adjusted for infant sex and gestational age were generated for each population separately and regressed on allele counts. Association evidence was combined across sites by inverse-variance weighted meta-analysis. Each additional C allele of rs900400 (LEKR1/CCNL1) in infants was marginally associated with a 0.069 SD lower birth weight (95% CI, -0.159 to 0.022; P = .068). This result was slightly more pronounced after adjusting for smoking (P = .036). No significant associations were identified with rs9883204 or in maternal samples. These results indicate the potential importance of this marker on birth weight regardless of gestational age.

Genome-Wide Association Study

Humans

Infant, Premature

Female

Male

Birth Weight - genetics

Infant, Newborn

Details

Title: Subtitle: Replication of a genome-wide association study of birth weight in preterm neonates
Creators: Kelli K Ryckman - Department of Pediatrics, University of Iowa, Iowa City, IA, USA
Bjarke Feenstra
John R Shaffer
Elise N A Bream
Frank Geller
Eleanor Feingold
Daniel E Weeks - University of Pittsburgh
Enrique Gadow
Viviana Cosentino
Cesar Saleme
Hyagriv N Simhan
David Merrill
Chin-To Fong
Tamara Busch
Susan K Berends
Belen Comas
Jorge L Camelo
Heather Boyd
Cathy C Laurie
David Crosslin
Kimberly F Doheny
Elizabeth Pugh
Mads Melbye
Mary L Marazita
John M Dagle
Qi Zhang - University of Washington
Jeffrey C Murray
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.160(1), pp.19-24.e4
DOI: 10.1016/j.jpeds.2011.07.038
PMID: 21885063
PMCID: PMC3237813
NLM abbreviation: J Pediatr
ISSN: 1097-6833
eISSN: 1097-6833
Publisher: United States
Grant note: R01 HD052953-05 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS T32 HL007638 / NHLBI NIH HHS R01 HD057192 / NICHD NIH HHS R01 HD057192-02 / NICHD NIH HHS U01 HG004446 / NHGRI NIH HHS R01 HD052953-04 / NICHD NIH HHS U01 HG004438 / NHGRI NIH HHS U01 HG004423 / NHGRI NIH HHS
Language: English
Date published: 01/2012
Academic Unit: Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9983995127002771

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