Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns

Kelli K Ryckman; Daniel E Cook; Stanton L Berberich; Oleg A Shchelochkov; Susan K Berends; Tamara Busch; John M Dagle; Jeffrey C Murray

doi:10.1515/jpem-2011-0456

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Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns

Journal article

Peer reviewed

Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns

Kelli K Ryckman, Daniel E Cook, Stanton L Berberich, Oleg A Shchelochkov, Susan K Berends, Tamara Busch, John M Dagle and Jeffrey C Murray

Journal of pediatric endocrinology & metabolism : JPEM, Vol.25(3-4), pp.301-305

2012

DOI: 10.1515/jpem-2011-0456

PMCID: PMC3552557

PMID: 22768660

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Abstract

Nationally, newborn screening programs use 17-hydroxyprogesterone (17-OHP) as the biomarker to detect the rare but potentially fatal inherited disease, congenital adrenal hyperplasia. However, this biomarker is highly variable, with a high false-positive rate of detection, particularly in neonates born preterm. Several studies have examined various clinical and genetic factors to explain the variability of 17-OHP in preterm infants. The purpose of this study was to replicate previous clinical and genetic associations with 17-OHP in a well-characterized cohort of 762 preterm infants. We replicated previous findings that respiratory distress syndrome (p = 2 x 10(-3)) is associated with higher 17-OHP. Higher 17-OHP and false positives were significantly associated with lower gestational age and birth weight, as previously reported. Incorporating gestational age and birth weight together decreases the false-positive rate.

Prognosis

Prospective Studies

Respiratory Distress Syndrome, Newborn - diagnosis

Humans

Infant

17-alpha-Hydroxyprogesterone - blood

Adrenal Hyperplasia, Congenital - genetics

Neonatal Screening

Gestational Age

Adrenal Hyperplasia, Congenital - blood

DNA - blood

DNA - genetics

Birth Weight

Respiratory Distress Syndrome, Newborn - blood

Adrenal Hyperplasia, Congenital - diagnosis

Infant, Premature

Respiratory Distress Syndrome, Newborn - genetics

Female

Retrospective Studies

Infant, Newborn

Details

Title: Subtitle: Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns
Creators: Kelli K Ryckman - Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA. kelli-ryckman@uiowa.edu
Daniel E Cook
Stanton L Berberich
Oleg A Shchelochkov
Susan K Berends
Tamara Busch
John M Dagle
Jeffrey C Murray
Resource Type: Journal article
Publication Details: Journal of pediatric endocrinology & metabolism : JPEM, Vol.25(3-4), pp.301-305
DOI: 10.1515/jpem-2011-0456
PMID: 22768660
PMCID: PMC3552557
NLM abbreviation: J Pediatr Endocrinol Metab
ISSN: 0334-018X
eISSN: 2191-0251
Publisher: Germany
Grant note: 5T32 HL007638-24 / NHLBI NIH HHS K99 HD-065786 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS T32 HL007638 / NHLBI NIH HHS R00 HD065786 / NICHD NIH HHS K99 HD065786 / NICHD NIH HHS R01 HD057192 / NICHD NIH HHS
Language: English
Date published: 2012
Academic Unit: Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Biochemistry and Molecular Biology; Dental Research; Neonatology
Record Identifier: 9983995016402771

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