Journal article
Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
NPJ breast cancer, Vol.6, 16
05/12/2020
DOI: 10.1038/s41523-020-0154-2
PMCID: PMC7217824
PMID: 32411818
Abstract
Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. We detail the benefits of computational TILs assessment, the readiness of TILs scoring for computational assessment, and outline considerations for overcoming key barriers to clinical translation in this arena. Specifically, we discuss: 1. ensuring computational workflows closely capture visual guidelines and standards; 2. challenges and thoughts standards for assessment of algorithms including training, preanalytical, analytical, and clinical validation; 3. perspectives on how to realize the potential of machine learning models and to overcome the perceptual and practical limits of visual scoring.
Details
- Title: Subtitle
- Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group
- Creators
- Mohamed AmgadElisabeth Specht StovgaardEva BalslevJeppe ThagaardWeijie ChenSarah DudgeonAshish SharmaJennifer K KernerCarsten DenkertYinyin YuanKhalid AbdulJabbarStephan WienertPeter SavasLeonie VoorwerkAndrew H BeckAnant MadabhushiJohan HartmanManu M SebastianHugo M HorlingsJan HudečekFrancesco CiompiDavid A MooreRajendra SinghElvire RoblinMarcelo Luiz BalancinMarie-Christine MathieuJochen K LennerzPawan KirtaniI-Chun ChenJeremy P BraybrookeGiancarlo PruneriSandra DemariaSylvia AdamsStuart J SchnittSunil R LakhaniFederico RojoLaura ComermaSunil S BadveMehrnoush KhojastehW. Fraser SymmansChristos SotiriouPaula Gonzalez-EricssonKatherine L Pogue-GeileRim S KimDavid L RimmGiuseppe VialeStephen M HewittJohn M. S BartlettFrédérique Penault-LlorcaShom GoelHuang-Chun LienSibylle LoiblZuzana KosSherene LoiMatthew G HannaStefan MichielsMarleen KokTorsten O NielsenAlexander J LazarZsuzsanna Bago-HorvathLoes F. S KooremanJeroen A. W. M van der LaakJoel SaltzBrandon D GallasUday KurkureMichael BarnesRoberto SalgadoLee A. D CooperAini HyytiäinenAkira I HidaAlastair ThompsonAlex LefevreAllen GownAmy LoAnna SapinoAndre MoreiraAndrea RichardsonAndrea VingianiAndrew M BellizziAndrew TuttAngel Guerrero-ZotanoAnita GrigoriadisAnna EhingerAnna C Garrido-CastroAnne Vincent-SalomonAnne-Vibeke LaenkholmAshley Cimino-MathewsAshok SrinivasanBalazs AcsBaljit SinghBenjamin CalhounBenjamin Haibe-KansBenjamin SolomonBibhusal ThapaBrad H NelsonCarlos CastanedaCarmen Ballesteroes-MerinoCarmen CriscitielloCarolien BoeckxCecile ColpaertCecily QuinnChakra S ChennubhotlaCharles SwantonCinzia SolinasCrispin HileyDamien DrubayDaniel BethmannDeborah A DillonDenis LarsimontDhanusha SabanathanDieter PeetersDimitrios ZardavasDoris HöflmayerDouglas B JohnsonE. Aubrey ThompsonEdi BrogiEdith PerezEhab A ElGabryElizabeth F BlackleyEmily ReisenbichlerEnrique BellolioEwa ChmielikFabien GaireFabrice AndreFang-I LuFarid Azmoudeh-ArdalanForbius Tina GruossoFranklin PealeFred R HirschFrederick KlaushenGabriela Acosta-HaabGelareh FarshidGert van den EyndenGiuseppe CuriglianoGiuseppe FlorisGlenn BroeckxHarmut KoeppenHarry R HaynesHeather McArthurHeikki JoensuuHelena OlofssonIan CreeIris NederlofIsabel FrahmIva BrcicJack ChanJacqueline A HallJames ZiaiJane BrockJelle WesselingJennifer GiltnaneJerome LemonnierJiping ZhaJoana M RibeiroJodi M CarterJohannes HainfellnerJohn Le QuesneJonathan W JucoJorge Reis-FilhoJose van den BergJoselyn SanchezJoseph SparanoJoël CucheroussetJuan Carlos ArayaJulien AdamJustin M BalkoKai SaegerKalliopi SiziopikouKaren Willard-GalloKarolina SikorskaKarsten WeberKeith E SteeleKenneth EmancipatorKhalid El BairiKim R. M BlenmanKimberly H AllisonKoen K van de VijverKonstanty KorskiLajos PusztaiLaurence BuisseretLeming ShiLiu Shi-wei - Sichuan Cancer HospitalLuciana MolineroM. Valeria EstradaMaartje van SeijenMagali Lacroix-TrikiMaggie C. U CheangMaise al BakirMarc van de VijverMaria Vittoria DieciMarlon C RebelattoMartine PiccartMatthew P GoetzMatthias PreusserMelinda E SandersMeredith M ReganMichael ChristieMichael MisialekMichail IgnatiadisMichiel de MaakerMieke van BockstalMiluska CastilloNadia HarbeckNadine TungNele LaudusNicolas SirtaineNicole BurchardiNils TernesNina Radosevic-RobinOleg GluzOliver GrimmPaolo NuciforoPaul JankPetar JelinicPeter H WatsonPrudence A FrancisPrudence A RussellRobert H PierceRobert HillsRoberto Leon-FerreRoland de WindRuohong ShuiSabine DeclercqSam LeungSami TabbarahSandra C SouzaSandra O’TooleSandra SwainScooter WillisScott ElySeong- Rim KimShahinaz BedriSheeba IrshadShi-Wei Liu - Peking University First HospitalShona HendrySimonetta BianchiSofia BragançaSoonmyung PaikStephen B FoxStephen J LuenStephen NaberSua LuzSusan FinebergTeresa SolerThomas GevaertTimothy d’AlfonsTom JohnTomohagu SugieVeerle BossuytVenkata ManemVincente Peg CámaeaWeida TongWentao YangWilliam T TranYihong WangYves AlloryZaheed Husain
- Resource Type
- Journal article
- Publication Details
- NPJ breast cancer, Vol.6, 16
- DOI
- 10.1038/s41523-020-0154-2
- PMID
- 32411818
- PMCID
- PMC7217824
- NLM abbreviation
- NPJ Breast Cancer
- ISSN
- 2374-4677
- Publisher
- Nature Publishing Group UK
- Grant note
- Funder: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) Funder: National Center for Research Resources under award number 1 C06 RR12463-01, VA Merit Review Award IBX004121A from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service, the DOD Prostate Cancer Idea Development Award (W81XWH-15-1-0558), the DOD Lung Cancer Investigator-Initiated Translational Research Award (W81XWH-18-1-0440), the DOD Peer Reviewed Cancer Research Program (W81XWH-16-1-0329), the Ohio Third Frontier Technology Validation Fund, the Wallace H. Coulter Foundation Program in the Department of Biomedical Engineering and the Clinical and Translational Science Award Program (CTSA) at Case Western Reserve University. Funder: Susan G Komen Foundation (CCR CCR18547966) and a Young Investigator Grant from the Breast Cancer Alliance. Funder: The Canadian Cancer Society Funder: Breast Cancer Research Foundation (BCRF), Grant No. 17-194
- Language
- English
- Date published
- 05/12/2020
- Academic Unit
- Pathology
- Record Identifier
- 9984199919902771
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