Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

Wassim W. Labaki; Tian Gu; Susan Murray; Charles R. Hatt; Craig J. Galbán; Brian D. Ross; Carlos H. Martinez; Jeffrey L. Curtis; Eric A. Hoffman; Esther Pompe; David A. Lynch; Ella A. Kazerooni; Fernando J. Martinez; MeiLan K. Han

doi:10.1016/j.acra.2019.02.003

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Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

Journal article

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Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers

Wassim W. Labaki, Tian Gu, Susan Murray, Charles R. Hatt, Craig J. Galbán, Brian D. Ross, Carlos H. Martinez, Jeffrey L. Curtis, Eric A. Hoffman, Esther Pompe, …

Academic radiology, Vol.26(3), pp.306-312

03/2019

DOI: 10.1016/j.acra.2019.02.003

PMCID: PMC6704470

PMID: 30792137

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Abstract

Chronic obstructive pulmonary disease is a heterogeneous disease characterized by small airway abnormality and emphysema. We hypothesized that a voxel-wise computed tomography analytic approach would identify patterns of disease progression in smokers. We analyzed 725 smokers in spirometric GOLD stages 0-4 with two chest CTs 5 years apart. Baseline inspiration, follow-up inspiration and follow-up expiration images were spatially registered to baseline expiration so that each voxel had correspondences across all time points and respiratory phases. Voxel-wise Parametric Response Mapping (PRM) was then generated for the baseline and follow-up scans. PRM classifies lung as normal, functional small airway disease (PRMfSAD), and emphysema (PRMEMPH). Subjects with low baseline PRMfSAD and PRMEMPH predominantly had an increase in PRMfSAD on follow-up; those with higher baseline PRMfSAD and PRMEMPH mostly had increases in PRMEMPH. For GOLD 0 participants (n = 419), mean 5-year increases in PRMfSAD and PRMEMPH were 0.3% for both; for GOLD 1–4 participants (n = 306), they were 0.6% and 1.6%, respectively. Eighty GOLD 0 subjects (19.1%) had overall radiologic progression (30.0% to PRMfSAD, 52.5% to PRMEMPH, and 17.5% to both); 153 GOLD 1–4 subjects (50.0%) experienced progression (17.6% to PRMfSAD, 48.4% to PRMEMPH, and 34.0% to both). In a multivariable model, both baseline PRMfSAD and PRMEMPH were associated with development of PRMEMPH on follow-up, although this relationship was diminished at higher levels of baseline PRMEMPH. A voxel-wise longitudinal PRM analytic approach can identify patterns of disease progression in smokers with and without chronic obstructive pulmonary disease.

Chronic obstructive pulmonary disease

Computed tomography

Emphysema

Parametric Response Mapping

Small airway disease

Details

Title: Subtitle: Reprint of: Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers
Creators: Wassim W. Labaki - Division of Pulmonary and Critical Care Medicine, University of Michigan, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI
Tian Gu - Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
Susan Murray - University of Michigan–Ann Arbor
Charles R. Hatt - Imbio LLC, Minneapolis, Minnesota
Craig J. Galbán - University of Michigan–Ann Arbor
Brian D. Ross - Imbio LLC, Minneapolis, Minnesota
Carlos H. Martinez - Division of Pulmonary and Critical Care Medicine, University of Michigan, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI
Jeffrey L. Curtis - Division of Pulmonary and Critical Care Medicine, University of Michigan, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI
Eric A. Hoffman - University of Iowa
Esther Pompe - Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
David A. Lynch - Department of Radiology, National Jewish Health, Denver, Colorado
Ella A. Kazerooni - Department of Radiology, University of Michigan, Ann Arbor, Michigan
Fernando J. Martinez - Division of Pulmonary and Critical Care Medicine, University of Michigan, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI
MeiLan K. Han - Division of Pulmonary and Critical Care Medicine, University of Michigan, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI
Resource Type: Journal article
Publication Details: Academic radiology, Vol.26(3), pp.306-312
Publisher: Elsevier Inc
DOI: 10.1016/j.acra.2019.02.003
PMID: 30792137
PMCID: PMC6704470
ISSN: 1076-6332
eISSN: 1878-4046
Grant note: name: U.S. National Heart, Lung and Blood Institute, award: R01HL089897, R01HL089856, NCT00608764; DOI: 10.13039/100008184, name: COPD Foundation; DOI: 10.13039/100000002, name: NIH, award: HHSN268200900013C, HHSN268200900014C, HHSN268200900015C, HHSN268200900016C, HHSN268200900017C, HHSN268200900018C, HHSN268200900019C, HHSN268200900020C; DOI: 10.13039/100000002, name: NIH, award: R01HL122438, R01HL126838, K24HL138188, T32HL007749
Language: English
Date published: 03/2019
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318711702771

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