Journal article
Reproducibility of Renal Perfusion MR Imaging in Native and Transplanted Kidneys Using Non-Contrast Arterial Spin Labeling
Journal of magnetic resonance imaging, Vol.33(6), pp.1414-1421
06/01/2011
DOI: 10.1002/jmri.22552
PMCID: PMC3098463
PMID: 21591011
Abstract
Purpose: To examine both inter-visit and intra-visit reproducibility of a MR arterial spin labeling (ASL) perfusion technique in native and transplanted kidneys over a broad range of renal function.
Materials and Methods: Renal perfusion exams were performed at 1.5 T in a total of 24 subjects: 10 with native and 14 with transplanted kidneys. Using a flow-sensitive alternating inversion recovery (FAIR) ASL scheme, 32 control/tag pairs were acquired and processed using a single-compartment model. Two FAIR-ASL MR exams were performed at least 24 h apart on all the subjects to assess inter-visit reproducibility. ASL perfusion measurements were also repeated back-to-back within one scanning session in 8 native subjects and in 12 transplant subjects to assess intra-visit reproducibility. Intra-class correlations (ICCs) and coefficients of variation (CVs) were calculated as metrics of reproducibility.
Results: Intra-visit ICCs ranged from 0.96 to 0.98 while CVs ranged from 4.8 to 6.0%. Inter-visit measurements demonstrated slightly more variation with ICCs from 0.89 to 0.94 and CVs from 7.6 to 13.1%. Medullary perfusion demonstrated greater variability compared with cortical blood flow: intra-visit ICCs from 0.72 to 0.78 and CVs from 16.7 to 26.7%, inter-visit ICCs from 0.13 to 0.63 and CVs from 19.8 to 37%.
Conclusion: This study indicates that a FAIR-ASL perfusion technique is reproducible in the cortex of native and transplanted kidneys over a broad range in renal function. In contrast, perfusion measurements in the medulla demonstrated moderate to poor reproducibility for intravisit and inter-visit measures respectively.
Details
- Title: Subtitle
- Reproducibility of Renal Perfusion MR Imaging in Native and Transplanted Kidneys Using Non-Contrast Arterial Spin Labeling
- Creators
- Nathan S. Artz - University of Wisconsin–MadisonElizabeth A. Sadowski - University of Wisconsin–MadisonAndrew L. Wentland - University of Wisconsin–MadisonArjang Djamali - University of Wisconsin–MadisonThomas M. Grist - University of Wisconsin–MadisonSongwon Seo - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Journal of magnetic resonance imaging, Vol.33(6), pp.1414-1421
- Publisher
- Wiley
- DOI
- 10.1002/jmri.22552
- PMID
- 21591011
- PMCID
- PMC3098463
- ISSN
- 1053-1807
- eISSN
- 1522-2586
- Number of pages
- 8
- Grant note
- R01DK073680 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) GE Healthcare; General Electric R01 DK 073680; R21 DK070243 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA T32GM008692 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 06/01/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology
- Record Identifier
- 9984274959002771
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