Journal article
Reproducibility of SD-OCT-based ganglion cell-layer thickness in glaucoma using two different segmentation algorithms
Investigative ophthalmology & visual science, Vol.54(10), pp.6998-7004
10/25/2013
DOI: 10.1167/iovs.13-12131
PMCID: PMC3809946
PMID: 24045993
Abstract
To compare the reproducibility of spectral-domain optical coherence tomography (SD-OCT)-based ganglion cell-layer-plus-inner plexiform-layer (GCL+IPL) thickness measurements for glaucoma patients obtained using both a publicly available and a commercially available algorithm. Macula SD-OCT volumes (200 × 200 × 1024 voxels, 6 × 6 × 2 mm(3)) were obtained prospectively from both eyes of patients with open-angle glaucoma or with suspected glaucoma on two separate visits within 4 months. The combined GCL+IPL thickness was computed for each SD-OCT volume within an elliptical annulus centered at the fovea, based on two algorithms: (1) a previously published graph-theoretical layer segmentation approach developed at the University of Iowa, and (2) a ganglion cell analysis module of version 6 of Cirrus software. The mean overall thickness of the elliptical annulus was computed as was the thickness within six sectors. For statistical analyses, eyes with an SD-OCT volume with low signal strength (<6), image acquisition errors, or errors in performing the commercial GCL+IPL analysis in at least one of the repeated acquisitions were excluded. Using 104 eyes (from 56 patients) with repeated measurements, we found the intraclass correlation coefficient for the overall elliptical annular GCL+IPL thickness to be 0.98 (95% confidence interval [CI]: 0.97-0.99) with the Iowa algorithm and 0.95 (95% CI: 0.93-0.97) with the Cirrus algorithm; the intervisit SDs were 1.55 μm (Iowa) and 2.45 μm (Cirrus); and the coefficients of variation were 2.2% (Iowa) and 3.5% (Cirrus), P < 0.0001. SD-OCT-based GCL+IPL thickness measurements in patients with early glaucoma are highly reproducible.
Details
- Title: Subtitle
- Reproducibility of SD-OCT-based ganglion cell-layer thickness in glaucoma using two different segmentation algorithms
- Creators
- Mona K Garvin - Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, IowaKyungmoo LeeTrudy L BurnsMichael D AbràmoffMilan SonkaYoung H Kwon
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.54(10), pp.6998-7004
- DOI
- 10.1167/iovs.13-12131
- PMID
- 24045993
- PMCID
- PMC3809946
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 1552-5783
- eISSN
- 1552-5783
- Publisher
- United States
- Grant note
- IK2 RX000728 / RRD VA R01 EB004640 / NIBIB NIH HHS R01 EY018853 / NEI NIH HHS R01 EY019112 / NEI NIH HHS R01 EY023279 / NEI NIH HHS
- Language
- English
- Date published
- 10/25/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Epidemiology; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9983806371302771
Metrics
23 Record Views