Journal article
Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans
Catheterization and cardiovascular interventions, Vol.60(1), pp.67-78
2003
DOI: 10.1002/ccd.10594
PMID: 12929106
Abstract
The purpose of this study was to assess the reproducibility of an in vivo methodology to reconstruct the lumen, plaque, and external elastic membrane (EEM) of coronary arteries and estimate endothelial shear stress (ESS). Ten coronary arteries without significant stenoses (five native and five stented arteries) were investigated. The 3D lumen and EEM boundaries of each coronary artery were determined by fusing end-diastolic intravascular ultrasound images with biplane coronary angiograms. Coronary flow was measured. Computational fluid dynamics was used to calculate local ESS. Complete data acquisition was then repeated. Analysis was performed on each data set in a blinded manner. The intertest correlation coefficients for all arteries for the two measurements of lumen radius, EEM radius, plaque thickness, and ESS were r = 0.96, 0.96, 0.94, 0.91, respectively (all P values < 0.0001). The 3D anatomy and ESS of human coronary arteries can be reproducibly estimated in vivo. This methodology provides a tool to examine the effect of ESS on atherogenesis, remodeling, and restenosis; the contribution of arterial remodeling and plaque growth to changes in the lumen; and the impact of new therapies.
Details
- Title: Subtitle
- Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans
- Creators
- Ahmet U COSKUN - Department of Mechanical, Industrial and Manufacturing Engineering, Northeastern University, Boston, Massachusetts, United StatesYerem YEGHIAZARIANS - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United StatesPeter H STONE - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United StatesScott KINLAY - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United StatesMaureen E CLARK - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United StatesOlusegun J ILEGBUSI - Department of Mechanical, Industrial and Manufacturing Engineering, Northeastern University, Boston, Massachusetts, United StatesAndreas WAHLE - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United StatesMilan SONKA - Department of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United StatesJeffrey J POPMA - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United StatesRichard E KUNTZ - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United StatesCharles L FELDMAN - Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts, United States
- Resource Type
- Journal article
- Publication Details
- Catheterization and cardiovascular interventions, Vol.60(1), pp.67-78
- DOI
- 10.1002/ccd.10594
- PMID
- 12929106
- NLM abbreviation
- Catheter Cardiovasc Interv
- ISSN
- 1522-1946
- eISSN
- 1522-726X
- Publisher
- Wiley-Liss; New York, NY
- Language
- English
- Date published
- 2003
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9984047626902771
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