Journal article
Reproducibility of diabetic macular edema estimates from SD-OCT is affected by the choice of image analysis algorithm
Investigative ophthalmology & visual science, Vol.54(6), pp.4184-4188
06/19/2013
DOI: 10.1167/iovs.12-10420
PMCID: PMC3687962
PMID: 23696607
Abstract
To evaluate the intersession repeatability of retinal thickness measurements in patients with diabetic macular edema (DME) using the Heidelberg Spectralis optical coherence tomography (OCT) algorithm and a publicly available, three-dimensional graph search-based multilayer OCT segmentation algorithm, the Iowa Reference Algorithm. Thirty eyes from 21 patients diagnosed with clinically significant DME were included and underwent consecutive, registered macula-centered spectral-domain optical coherence scans (Heidelberg Spectralis). The OCT scans were segmented into separate surfaces, and the average thickness between internal limiting membrane and outer retinal pigment epithelium complex surfaces was determined using the Iowa Reference Algorithm. Variability between paired scans was analyzed and compared with the retinal thickness obtained from the manufacturer-supplied Spectralis software. The coefficient of repeatability (variation) for central macular thickness using the Iowa Reference Algorithm was 5.26 μm (0.62% [95% confidence interval (CI), 0.43-0.71]), while for the Spectralis algorithm this was 6.84 μm (0.81% [95% CI, 0.55-0.92]). When the central 3 mm was analyzed, the coefficient of repeatability (variation) was 2.46 μm (0.31% [95% CI, 0.23-0.38]) for the Iowa Reference Algorithm and 4.23 μm (0.53% [95% CI, 0.39-0.65]) for the Spectralis software. The Iowa Reference Algorithm and the Spectralis software provide excellent reproducibility between serial scans in patients with clinically significant DME. The publicly available Iowa Reference Algorithm may have lower between-measurement variation than the manufacturer-supplied Spectralis software for the central 3 mm subfield. These findings have significant implications for the management of patients with DME.
Details
- Title: Subtitle
- Reproducibility of diabetic macular edema estimates from SD-OCT is affected by the choice of image analysis algorithm
- Creators
- Elliott H Sohn - Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USAJohn J ChenKyungmoo LeeMeindert NiemeijerMilan SonkaMichael D Abràmoff
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.54(6), pp.4184-4188
- DOI
- 10.1167/iovs.12-10420
- PMID
- 23696607
- PMCID
- PMC3687962
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 1552-5783
- eISSN
- 1552-5783
- Publisher
- United States
- Grant note
- R01 EY019112 / NEI NIH HHS R01 EB004640 / NIBIB NIH HHS R01 EY018853 / NEI NIH HHS
- Language
- English
- Date published
- 06/19/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Radiation Oncology; Injury Prevention Research Center; Ophthalmology and Visual Sciences
- Record Identifier
- 9983806267202771
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