Journal article
Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy
The journal of applied laboratory medicine, Vol.6(1), pp.41-50
01/12/2021
DOI: 10.1093/jalm/jfaa169
PMID: 33241847
Abstract
Gender-affirming therapy with testosterone is commonly prescribed to aid in the masculinization of transgender men. Sex-hormone concentrations are routinely measured, but interpretation of results can be difficult due to the lack of published reference intervals.
Healthy transgender individuals who had been prescribed testosterone (n = 82) for at least a year were recruited from internal medicine and primary care clinics that specialize in transgender medical care. Total testosterone and estradiol were measured using immunoassay and mass spectrometry; LH, FSH, SHBG, prolactin, progesterone, anti-Müllerian hormone (AMH), and dehydroepiandrosterone sulfate (DHEAS) were measured using immunoassay; free testosterone was calculated. Reference intervals (central 95%) were calculated according to Clinical Laboratory Standards Institute guidelines.
When evaluating general endocrine laboratory tests in people using masculinizing hormones, reference intervals for cisgender men can be applied for total and free testosterone and SHBG and reference intervals for cisgender women can be applied for prolactin. Reference intervals for estradiol, LH, FSH, AMH, and DHEAS differ from those used for cisgender men and cisgender women, and therefore should be interpreted using intervals specific to the transmasculine population. For testosterone and estradiol, results from immunoassays were clinically equivalent to mass spectrometry.
Masculinizing hormones will alter the concentrations of commonly evaluated endocrine hormones. Providers and laboratories should use appropriate reference intervals to interpret the results of these tests.
Details
- Title: Subtitle
- Reproductive Endocrinology Reference Intervals for Transgender Men on Stable Hormone Therapy
- Creators
- Dina N Greene - University of WashingtonRobert L Schmidt - University of UtahGabrielle Winston-McPherson - University of WashingtonJessica Rongitsch - Capitol Hill Medical, Seattle, WAKatherine L Imborek - University of Iowa Hospitals and ClinicsJane A Dickerson - Seattle Children's HospitalJulia C Drees - The Permanente Medical Group Regional Laboratories, Richmond, CARobert M Humble - University of Iowa Hospitals and ClinicsNicole Nisly - University of Iowa Hospitals and ClinicsNancy J Dole - University of Iowa Hospitals and ClinicsSusan K Dane - University of Iowa Hospitals and ClinicsJanice Frerichs - University of Iowa Hospitals and ClinicsMatthew D Krasowski - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- The journal of applied laboratory medicine, Vol.6(1), pp.41-50
- DOI
- 10.1093/jalm/jfaa169
- PMID
- 33241847
- ISSN
- 2576-9456
- eISSN
- 2475-7241
- Language
- English
- Date published
- 01/12/2021
- Academic Unit
- Pathology; Gender, Women's and Sexuality Studies; Family and Community Medicine; General Internal Medicine; Internal Medicine
- Record Identifier
- 9984186507202771
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