Reproductive factors and risk of brain, colon, and other malignancies in Iowa (United States)

Kenneth P Cantor; Charles F Lynch; Doretta Johnson

doi:10.1007/BF00052425

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Reproductive factors and risk of brain, colon, and other malignancies in Iowa (United States)

Journal article

Peer reviewed

Reproductive factors and risk of brain, colon, and other malignancies in Iowa (United States)

Kenneth P Cantor, Charles F Lynch and Doretta Johnson

Cancer causes & control, Vol.4(6), pp.505-511

11/1993

DOI: 10.1007/BF00052425

PMID: 8280827

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Abstract

The influence of parity on the risk of cancers of the female breast and reproductive organs is well established. However, non-reproductive sites have received less attention. Mail questionnaire data gathered from incident female cases (169 brain; 332 colon; 260 rectal; 145 kidney; and 169 pancreas cancers), and 821 population-based controls in Iowa (United States) were used to measure the effect of parity and age at first birth on risk of these malignancies. Relative to nulliparous women, ever-parous women were at significantly decreased risk of brain cancer (odds ratio [OR] = 0.44, 95 percent confidence interval [CI] = 0.3-0.7) and of colon cancer (OR = 0.67, CI = 0.5-0.97), after adjustment for age and other risk factors. The OR for the other sites did not differ significantly from 1.0. The lower risk of brain cancer among parous women was similar in younger and older age groups, in patients diagnosed with glioblastoma and astrocytoma, and among ever- and never-smokers. The findings for colon cancer are consistent with observations from other studies. In the context of limited laboratory and clinical evidence implicating hormones in brain neoplasia, these findings may suggest a role for hormonal factors in brain cancer etiology. Hormonal factors deserve more detailed future consideration as risk factors in brain cancer.

Reproduction

Kidney Neoplasms - epidemiology

Pancreatic Neoplasms - epidemiology

Humans

Middle Aged

Risk Factors

Colonic Neoplasms - epidemiology

Rectal Neoplasms - epidemiology

Brain Neoplasms - metabolism

Case-Control Studies

Colonic Neoplasms - metabolism

Incidence

Maternal Age

Aged, 80 and over

Adult

Female

Iowa - epidemiology

Aged

Hormones - physiology

Odds Ratio

Parity

Neoplasms - epidemiology

Brain Neoplasms - epidemiology

Details

Title: Subtitle: Reproductive factors and risk of brain, colon, and other malignancies in Iowa (United States)
Creators: Kenneth P Cantor - Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD
Charles F Lynch
Doretta Johnson - University of Iowa
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.4(6), pp.505-511
DOI: 10.1007/BF00052425
PMID: 8280827
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: NCI NO1-CP-85614 / NCI NIH HHS NCI-NO1-CP-51026 / NCI NIH HHS 5 KO7 CA01181-05 / NCI NIH HHS
Language: English
Date published: 11/1993
Academic Unit: Epidemiology
Record Identifier: 9983996085502771

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