Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study

Jenny N Poynter; Bryan Langholz; Joan Largent; Lene Mellemkjaer; Leslie Bernstein; Kathleen E Malone; Charles F Lynch; Ake Borg; Patrick Concannon; Sharon N Teraoka; Shanyan Xue; Anh T Diep; Therese Törngren; Colin B Begg; Marinela Capanu; Robert W Haile; Jonine L Bernstein; WECARE Study Collaborative Group

doi:10.1007/s10552-010-9510-0

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Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study

Journal article

Peer reviewed

Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study

Jenny N Poynter, Bryan Langholz, Joan Largent, Lene Mellemkjaer, Leslie Bernstein, Kathleen E Malone, Charles F Lynch, Ake Borg, Patrick Concannon, Sharon N Teraoka, …

Cancer causes & control, Vol.21(6), pp.839-846

06/2010

DOI: 10.1007/s10552-010-9510-0

PMCID: PMC2873079

PMID: 20130978

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Abstract

Reproductive factors, such as early age at menarche, late age at menopause, and nulliparity are known risk factors for breast cancer. Previously, we reported these factors to be associated with risk of developing contralateral breast cancer (CBC). In this study, we evaluated the association between these factors and CBC risk among BRCA1 and BRCA2 (BRCA1/2) mutation carriers and non-carriers. The WECARE Study is a population-based multi-center case-control study of 705 women with CBC (cases) and 1,397 women with unilateral breast cancer (controls). All participants were screened for BRCA1/2 mutations and 181 carriers were identified. Conditional logistic regression models were used to evaluate associations between reproductive factors and CBC for mutation carriers and non-carriers. None of the associations between reproductive factors and CBC risk differed between mutation carriers and non-carriers. The increase in risk with younger age at menarche and decrease in risk in women with more than two full-term pregnancies seen in non-carriers were not significantly different in carriers (adjusted RRs = 1.31, 95% CI 0.65-2.65 and 0.53, 95% CI 0.19-1.51, respectively). No significant associations between the other reproductive factors and CBC risk were observed in mutation carriers or non-carriers. For two reproductive factors previously shown to be associated with CBC risk, we observed similar associations for BRCA1/2 carriers. This suggests that reproductive variables that affect CBC risk may have similar effects in mutation carriers and non-carriers.

Mutation

Pregnancy

Menarche - genetics

Humans

Menopause - genetics

Risk Factors

Logistic Models

Risk

Case-Control Studies

Breast Neoplasms - genetics

Neoplasms - chemically induced

Parity - genetics

Neoplasms - genetics

Genes, BRCA2

Reproductive History

Female

Breast Neoplasms - chemically induced

BRCA2 Protein - genetics

Details

Title: Subtitle: Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study
Creators: Jenny N Poynter - Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA. poynt006@umn.edu
Bryan Langholz
Joan Largent
Lene Mellemkjaer
Leslie Bernstein
Kathleen E Malone
Charles F Lynch
Ake Borg
Patrick Concannon
Sharon N Teraoka
Shanyan Xue - University of Southern California
Anh T Diep
Therese Törngren
Colin B Begg
Marinela Capanu
Robert W Haile
Jonine L Bernstein
WECARE Study Collaborative Group
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.21(6), pp.839-846
DOI: 10.1007/s10552-010-9510-0
PMID: 20130978
PMCID: PMC2873079
NLM abbreviation: Cancer Causes Control
ISSN: 0957-5243
eISSN: 1573-7225
Publisher: Netherlands
Grant note: R01 CA129639 / NCI NIH HHS T32 CA009142 / NCI NIH HHS U01 CA083178 / NCI NIH HHS R01 AG014358 / NIA NIH HHS U01 CA083178-05 / NCI NIH HHS R01CA097397 / NCI NIH HHS R01 CA097397 / NCI NIH HHS R01 CA097397-05 / NCI NIH HHS U01CA083178 / NCI NIH HHS T32 CA009142-30 / NCI NIH HHS
Language: English
Date published: 06/2010
Academic Unit: Epidemiology
Record Identifier: 9983995153502771

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