Reproductive history and risk of second primary breast cancer: the WECARE study

Joan A Largent; Marinela Capanu; Leslie Bernstein; Bryan Langholz; Lene Mellemkaer; Kathleen E Malone; Colin B Begg; Robert W Haile; Charles F Lynch; Hoda Anton-Culver; Abigail Wolitzer; Jonine L Bernstein

doi:10.1158/1055-9965.EPI-06-1003

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Reproductive history and risk of second primary breast cancer: the WECARE study

Journal article

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Reproductive history and risk of second primary breast cancer: the WECARE study

Joan A Largent, Marinela Capanu, Leslie Bernstein, Bryan Langholz, Lene Mellemkaer, Kathleen E Malone, Colin B Begg, Robert W Haile, Charles F Lynch, Hoda Anton-Culver, …

Cancer epidemiology, biomarkers & prevention, Vol.16(5), pp.906-911

05/2007

DOI: 10.1158/1055-9965.EPI-06-1003

PMID: 17507614

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Abstract

Women with an initial breast cancer diagnosis are at elevated risk of developing subsequent cancer in the contralateral breast. Studies of reproductive factors and contralateral breast cancer (CBC) have provided inconsistent results. We employed a case-control study nested within five population-based cancer registries in the United States and Denmark to examine associations between reproductive history and CBC risk. Cases were women with asynchronous CBC who had their first primary invasive breast cancer before age 55 years. Two controls, who had only one primary breast cancer diagnosis, were individually matched to each case on age and year of diagnosis, race, and registry. A total of 694 case-control triplets and 11 case-control pairs were enrolled. Information regarding possible CBC risk factors was obtained via telephone interviews. Multivariable conditional logistic regression was used to estimate rate ratios (RR) and 95% confidence intervals (95% CI) associated with risk factors of interest. Increasing number of full-term pregnancies (FTP) was inversely associated with CBC risk (P trend, 0.001). Women who reported menarche before age 13 years had an increased risk of CBC (RR, 1.26; 95% CI, 1.01-1.58). Age at first FTP, breastfeeding history, and age at menopause were not significantly associated with CBC risk. These results suggest age at menarche and parity, which are established risk factors for first primary breast cancer, are associated with CBC, whereas other reproductive risk factors associated with first primary breast cancer, such as age at first FTP, are less important factors in the development of CBC.

United States - epidemiology

Age Factors

Humans

Menopause

Middle Aged

Breast Feeding

Menarche

Case-Control Studies

Adult

Female

Interviews as Topic

Registries

Surveys and Questionnaires

Parity

Breast Neoplasms - epidemiology

Neoplasm Invasiveness

Risk Factors

Logistic Models

Neoplasms, Second Primary - epidemiology

Pregnancy

Breast Neoplasms - pathology

Denmark - epidemiology

Reproductive History

Aged

Gravidity

Neoplasms, Second Primary - pathology

Cohort Studies

Details

Title: Subtitle: Reproductive history and risk of second primary breast cancer: the WECARE study
Creators: Joan A Largent - Epidemiology Division, Department of Medicine, University of California, Irvine, Irvine, CA 92697-7555, USA. jlargent@uci.edu
Marinela Capanu
Leslie Bernstein
Bryan Langholz
Lene Mellemkaer
Kathleen E Malone
Colin B Begg
Robert W Haile
Charles F Lynch
Hoda Anton-Culver
Abigail Wolitzer
Jonine L Bernstein
Resource Type: Journal article
Publication Details: Cancer epidemiology, biomarkers & prevention, Vol.16(5), pp.906-911
DOI: 10.1158/1055-9965.EPI-06-1003
PMID: 17507614
NLM abbreviation: Cancer Epidemiol Biomarkers Prev
ISSN: 1055-9965
eISSN: 1538-7755
Publisher: United States
Grant note: R01 CA129639 / NCI NIH HHS R01CA97397 / NCI NIH HHS U01CA83178 / NCI NIH HHS
Language: English
Date published: 05/2007
Academic Unit: Epidemiology
Record Identifier: 9983995113602771

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