Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease

Marhiah C Montoya; Damian J Krysan

doi:10.1128/mBio.02272-18

Back

Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease

Journal article

Open access

Peer reviewed

Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease

Marhiah C Montoya and Damian J Krysan

mBio, Vol.9(6), p.e02272-18

12/18/2018

DOI: 10.1128/mBio.02272-18

PMCID: PMC6299222

PMID: 30563895

Files and links (1)

url

https://doi.org/10.1128/mBio.02272-18View

Published (Version of record) Open Access

Abstract

The concept of repurposing previously approved medications to the treatment of new indications by taking advantage of off-target effects has gained traction in recent years, particularly in areas of medicine that do not offer large profits to pharmaceutical firms. As infectious disease discovery research has declined among large pharmaceutical companies, the potential payoff of repurposing has become attractive. From these efforts, the triphenylethylene class of selective estrogen receptor modulators related to tamoxifen has shown activity against a wide range of medically important human pathogens, including bacteria, fungi, parasites, and viruses. Because it has activity against many pathogens affecting people in resource-limited areas of the world, TAM and related drugs may be particularly useful. Here, we review the , , and mechanistic studies of the anti-infective activity of tamoxifen, toremifene, clomiphene, and their analogs. We also discuss the pharmacologic properties of this privileged scaffold and its potential utility in treating infectious diseases.

Stilbenes - therapeutic use

Humans

Bacteria - drug effects

Toremifene - analogs & derivatives

Viruses - drug effects

Drug Repositioning

Estrogen Receptor Antagonists - pharmacology

Parasites - drug effects

Animals

Communicable Diseases - drug therapy

Tamoxifen - pharmacology

Tamoxifen - analogs & derivatives

Female

Mice

Toremifene - pharmacology

Details

Title: Subtitle: Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease
Creators: Marhiah C Montoya - Department of Microbiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Damian J Krysan - Department of Microbiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Resource Type: Journal article
Publication Details: mBio, Vol.9(6), p.e02272-18
DOI: 10.1128/mBio.02272-18
PMID: 30563895
PMCID: PMC6299222
NLM abbreviation: mBio
ISSN: 2161-2129
eISSN: 2150-7511
Grant note: DOI: 10.13039/100000060, name: National Institute of Allergy and Infectious Diseases, award: R21 AI125094-02
Language: English
Date published: 12/18/2018
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093355902771

Metrics

17 Record Views

50 Times Cited - Web of Science