Journal article
Repurposing of the anti-HIV drug emtricitabine as a hydrogen-bonded cleft for bipyridines via cocrystallization
CrystEngComm, Vol.22(21), pp.3563-3566
06/01/2020
DOI: 10.1039/D0CE00474J
Abstract
We report supramolecular repurposing of emtricitabine (FTC, trade name: Emtriva®), a blockbuster FDA-approved anti-HIV agent. FTC is revealed to act as a hydrogen-bonded cleft for bipyridine recognition. The supramolecular repurposing is realized by the generation of four cocrystals through liquid-assisted grinding. The clefts comprise discrete three-component assemblies sustained by a combination of hydrogen bonds and π⋯π interactions.
Details
- Title: Subtitle
- Repurposing of the anti-HIV drug emtricitabine as a hydrogen-bonded cleft for bipyridines via cocrystallization
- Creators
- Gonzalo Campillo-Alvarado - Department of Chemistry, University of Iowa, Iowa City, USAElizabeth A Keene - Department of Chemistry, University of Iowa, Iowa City, USADale C Swenson - Department of Chemistry, University of Iowa, Iowa City, USALeonard R MacGillivray - Department of Chemistry, University of Iowa, Iowa City, USA
- Resource Type
- Journal article
- Publication Details
- CrystEngComm, Vol.22(21), pp.3563-3566
- DOI
- 10.1039/D0CE00474J
- ISSN
- 1466-8033
- eISSN
- 1466-8033
- Grant note
- DOI: 10.13039/100000001, name: National Science Foundation, award: DMR-1708673; DOI: 10.13039/501100003141, name: Consejo Nacional de Ciencia y Tecnología
- Language
- English
- Date published
- 06/01/2020
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Chemistry
- Record Identifier
- 9984216722202771
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